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Immunopathogenesis of ANCA-Associated Vasculitis
- Source :
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, International Journal of Molecular Sciences, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.1-27. ⟨10.3390/ijms21197319⟩, International Journal of Molecular Sciences, Vol 21, Iss 7319, p 7319 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute (MDPI), 2020.
-
Abstract
- International audience; Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune disorder which affects small-and, to a lesser degree, medium-sized vessels. ANCA-associated vasculitis encompasses three disease phenotypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). This classification is largely based on clinical presentations and has several limitations. Recent research provided evidence that genetic background, risk of relapse, prognosis, and co-morbidities are more closely related to the ANCA serotype, proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA, compared to the disease phenotypes GPA or MPA. This finding has been extended to the investigation of biomarkers predicting disease activity, which again more closely relate to the ANCA serotype. Discoveries related to the immunopathogenesis translated into clinical practice as targeted therapies are on the rise. This review will summarize the current understanding of the immunopathogenesis of ANCA-associated vasculitis and the interplay between ANCA serotype and proposed disease biomarkers and illustrate how the extending knowledge of the immunopathogenesis will likely translate into development of a personalized medicine approach in the management of ANCA-associated vasculitis.
- Subjects :
- 0301 basic medicine
[SDV]Life Sciences [q-bio]
Microscopic Polyangiitis
Review
Churg-Strauss Syndrome
urologic and male genital diseases
lcsh:Chemistry
0302 clinical medicine
Proteinase 3
immune system diseases
Eosinophilic
skin and connective tissue diseases
lcsh:QH301-705.5
Spectroscopy
biology
treatment
ANCA
pathogenesis
General Medicine
Prognosis
3. Good health
Computer Science Applications
Myeloperoxidase
Biomarker (medicine)
biomarker
Microscopic polyangiitis
Granulomatosis with polyangiitis
Vasculitis
phenotype
Myeloblastin
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Serogroup
Catalysis
Antibodies, Antineutrophil Cytoplasmic
Inorganic Chemistry
03 medical and health sciences
medicine
Humans
cardiovascular diseases
Physical and Theoretical Chemistry
Molecular Biology
Peroxidase
030203 arthritis & rheumatology
business.industry
Organic Chemistry
Granulomatosis with Polyangiitis
medicine.disease
respiratory tract diseases
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Immunology
biology.protein
Personalized medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 16616596 and 14220067
- Database :
- OpenAIRE
- Journal :
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu, International Journal of Molecular Sciences, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, International Journal of Molecular Sciences, MDPI, 2020, 21 (19), pp.1-27. ⟨10.3390/ijms21197319⟩, International Journal of Molecular Sciences, Vol 21, Iss 7319, p 7319 (2020)
- Accession number :
- edsair.doi.dedup.....98a1fa6875865c406d91302006b67aef