Back to Search Start Over

Single-cell RNA-seq recognized the initiator of epithelial ovarian cancer recurrence

Authors :
Tongtong Kan
Shupeng Zhang
Shengtao Zhou
Ya Zhang
Yun Zhao
Yinghua Gao
Tao Zhang
Feng Gao
Xin Wang
Linjie Zhao
Mengsu Yang
Source :
Oncogene. 41:895-906
Publication Year :
2022
Publisher :
Springer Science and Business Media LLC, 2022.

Abstract

Epithelial ovarian cancers (EOCs) are sensitive to chemotherapy but will ultimately relapse and develop drug resistance. The origin of EOC recurrence has been elusive due to intra-tumor heterogeneity. Here we performed single-cell RNA sequencing (scRNA-seq) in 13,369 cells from primary, untreated peritoneal metastasis, and relapse tumors. We used time-resolved analysis to chart the developmental sequence of cells from the metastatic tumors, then traced the earliest replanting cells back to the primary tumors. We discovered seven distinct subpopulations in primary tumors where the CYR61

Details

ISSN :
14765594 and 09509232
Volume :
41
Database :
OpenAIRE
Journal :
Oncogene
Accession number :
edsair.doi.dedup.....98e0666d2624080f4ecdb99adb55f347