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Comparative effects of liraglutide 3 mg vs structured lifestyle modification on body weight, liver fat and liver function in obese patients with non-alcoholic fatty liver disease: A pilot randomized trial
- Source :
- Diabetes, obesitymetabolism. 19(12)
- Publication Year :
- 2017
-
Abstract
- We compared the effects of weight loss induced by the glucagon-like peptide 1-agonist liraglutide with a structured lifestyle intervention in obese adults with non-alcoholic fatty liver disease (NAFLD). Obese (body mass index ≥30 kg/m2 , mean weight 96.0 ± 16.3 kg) non-diabetic Asian adults, with NAFLD diagnosed by liver fat fraction (LFF) ≥ 5.5% on magnetic resonance imaging without other causes of hepatic steatosis, were randomized to a supervised program of dieting (restriction by 400 kilocalories/d) plus moderate-intensity aerobic exercise (~200 min/wk; DE group, n = 12), or liraglutide at the 3 mg daily dose approved for weight loss (LI group, n = 12), for 26 weeks. Both DE and LI groups had significant (P < .01) and similar reductions in weight (-3.5 ± 3.3 vs -3.5 ± 2.1 kg, respectively, P = .72), LFF (-8.9 ± 13.4 vs -7.2% ± 7.1%, P = .70), serum alanine aminotransferase (-42 ± 46 vs -34 ± 27 U/L, P = .52) and aspartate aminotransferase (-23 ± 24 vs -18 ± 15 U/L, P = .53). In this first randomized study comparing the 2 weight-loss modalities for improving NAFLD, liraglutide was as effective as structured lifestyle modification.
- Subjects :
- Adult
Male
medicine.medical_specialty
Diet, Reducing
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Pilot Projects
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin resistance
Weight loss
Non-alcoholic Fatty Liver Disease
Internal medicine
Weight Loss
Internal Medicine
medicine
Aerobic exercise
Humans
Hypoglycemic Agents
Healthy Lifestyle
Obesity
Exercise
Caloric Restriction
Singapore
Liraglutide
business.industry
Fatty liver
Middle Aged
medicine.disease
Lipid Metabolism
Magnetic Resonance Imaging
Liver
030211 gastroenterology & hepatology
Female
Liver function
medicine.symptom
Insulin Resistance
Waist Circumference
business
Body mass index
medicine.drug
Dieting
Subjects
Details
- ISSN :
- 14631326
- Volume :
- 19
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Diabetes, obesitymetabolism
- Accession number :
- edsair.doi.dedup.....98e3b26b79e501680272d924ae97e4bd