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Malignancies in Italian patients with systemic sclerosis positive for anti-RNA polymerase III antibodies
- Publication Year :
- 2011
-
Abstract
- Objective.To evaluate the frequency of malignancies in Italian patients with systemic sclerosis (SSc) and anti-RNA polymerase III (RNAP III), antitopoisomerase I (topo I), or anticentromere antibodies (ACA); and to characterize the temporal relationship between the 2 diseases, in order to confirm data suggesting a close temporal relationship between the onset of SSc and malignancy in American patients with anti-RNAP III antibodies.Methods.From a cohort of 466 consecutive SSc patients, 360 Italians with isolated positivity for anti-RNAP III (n = 16), anti-topo I (n = 101), or ACA (n = 243) were identified. Malignancy cases were divided according to their relationship with SSc onset into 3 categories: preceding, synchronous with, or metachronous to the onset of SSc (diagnosed more than 6 months before; 6 months before to 12 months after; and more than 12 months after onset of SSc, respectively).Results.Malignancies were more frequent in the anti-RNAP III group (7/16 patients), than in the anti-topo I (11/101) and ACA groups (21/243) (p < 0.001). This difference was accounted for by the number of patients with cancer synchronous to the onset of SSc (3/16 in the anti-RNAP III group vs 0/101 in the anti-topo I and 1/243 in the ACA group; p < 0.001), whereas neither the number of malignancies preceding nor those metachronous to the onset of SSc was significantly different between the groups.Conclusion.In a cohort of Italian patients with SSc we observed a significant association between malignancies synchronous to SSc onset and positivity for anti-RNAP III antibodies, similar to that described in American patients with SSc.
- Subjects :
- Male
Pathology
Esophageal Neoplasms
Lymphoma
Anticentromere antibodies
Type I
Comorbidity
Anti-RNA polymerase III antibodies
Gastroenterology
Scleroderma
Cohort Studies
Antinuclear
Neoplasms
Ductal
Prevalence
Medicine
Immunology and Allergy
Breast
skin and connective tissue diseases
integumentary system
biology
Lymphoma, Non-Hodgkin
Carcinoma, Ductal, Breast
Antitopoisomerase I antibodies
Malignancy
Systemic sclerosis
Adult
Aged
Antibodies, Anti-Idiotypic
Antibodies, Antinuclear
Breast Neoplasms
Carcinoma, Squamous Cell
DNA Topoisomerases, Type I
Female
Follow-Up Studies
Humans
Italy
Middle Aged
RNA Polymerase III
Retrospective Studies
Scleroderma, Systemic
Rheumatology
Immunology
Anti-Idiotypic
Cohort
Antibody
medicine.medical_specialty
Non-Hodgkin
RNA polymerase III
Antibodies
Internal medicine
business.industry
Carcinoma
Systemic
medicine.disease
Squamous Cell
biology.protein
business
DNA Topoisomerases
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....98e3febb8657fd673af3e1b2942a606a