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Platelet count and sustained virological response in hepatitis C treatment
- Source :
- World journal of hepatology. 5(4)
- Publication Year :
- 2012
-
Abstract
- AIM: To examine the epidemiological data, hematological safety and treatment responses of peginterferon-alpha 2a plus ribavirin therapy for hepatitis C. METHODS: Between March 2008 and February 2011, 196 hepatitis C virus (HCV) genotype 1 infected Japanese (127 treatment-naive and 69 treatment-experienced patients) patients treated with peginterferon-alpha 2a plus ribavirin were enrolled. We examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological safety. HCV RNA was measured by the COBAS TaqMan HCV test. RESULTS: Overall sustained virological response (SVR) rates of treatment-naive and treatment-experienced patients were 56% and 39%, respectively. Multivariate logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced patients. SVR rates did not differ between the pretreatment hemoglobin < 13 g/dL and ≥ 13 g/dL groups. However, in treatment-naive patients, the SVR rate of the pretreatment platelet count < 130000/µL group was significantly lower than that of the pretreatment platelet count ≥ 130000/µL group. CONCLUSION: Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients.
- Subjects :
- Hepatitis
medicine.medical_specialty
Hepatology
Anemia
business.industry
Hepatitis C virus
Ribavirin
virus diseases
Hepatitis C
medicine.disease
medicine.disease_cause
Logistic regression
Gastroenterology
digestive system diseases
chemistry.chemical_compound
chemistry
Internal medicine
Epidemiology
Immunology
medicine
Platelet
Original Article
business
Subjects
Details
- ISSN :
- 19485182
- Volume :
- 5
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- World journal of hepatology
- Accession number :
- edsair.doi.dedup.....98ec7b52788db18f4722157425f7d9ab