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Impact of Adjuvant Intravesical Bacillus Calmette-Guérin Treatment on Patients with High-Grade T1 Bladder Cancer
- Source :
- Urologia internationalis. 96(2)
- Publication Year :
- 2015
-
Abstract
- Purpose: To evaluate the impact of adjuvant intravesical bacillus Calmette-Guérin (BCG) treatment in patients with high-grade transitional cell carcinoma of bladder. Patients and Methods: A total of 207 consecutive patients who underwent transurethral resection for high-grade T1 transitional cell carcinoma of bladder at our institution between January 1, 2005 and December 31, 2012. Of those patients, 77 underwent early cystectomy without BCG instillation and were excluded from the analysis. The overall survival and cancer-specific mortality were compared in 2 different therapy options groups (group of patients who received adjuvant BCG instillation vs. the group of patients who did not receive BCG therapy). Overall mortality was estimated by the Kaplan-Meier method, univariate comparisons were made with the log rank test. The cumulative incidence of deaths from bladder cancer (BC) was determined by univariate and multivariate competing risk analysis. Cox proportional hazard models for competing risks were used to study the combined effects of the variables on BC-specific mortality. Results: The 5-year overall survival in patients with BCG instillation vs. patients who did not receive BCG therapy was 74 vs. 28% (p = 0.0016). In the univariate analysis, the adjuvant intravesical BCG treatment was associated with decreased cancer-specific mortality (p = 0.0062). In the multivariable analysis, the age and the BCG instillation were independent factors of overall survival (hazard ratio 0.26, 95% CI 0.15-0.46, p < 0.0001) and cancer-specific mortality (hazard ratio 0.29, 95% CI 0.12-0.71, p = 0.0067). Conclusion: Dispensing from adjuvant intravesical BCG treatment is associated with increased overall- and disease-specific mortality in patients with T1 high-grade transitional cell carcinoma of bladder. This observation confirms that adjuvant BCG instillation is a crucial part of treatment in this patient population.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Urology
medicine.medical_treatment
030232 urology & nephrology
Antineoplastic Agents
Kaplan-Meier Estimate
Cystectomy
03 medical and health sciences
0302 clinical medicine
Risk Factors
Odds Ratio
Medicine
Humans
Cumulative incidence
Aged
Proportional Hazards Models
Retrospective Studies
Aged, 80 and over
Univariate analysis
Carcinoma, Transitional Cell
Bladder cancer
business.industry
Proportional hazards model
Hazard ratio
Middle Aged
medicine.disease
Surgery
Transitional cell carcinoma
Administration, Intravesical
Logistic Models
Treatment Outcome
Urinary Bladder Neoplasms
Chemotherapy, Adjuvant
030220 oncology & carcinogenesis
Multivariate Analysis
BCG Vaccine
Female
Neoplasm Grading
business
BCG vaccine
Subjects
Details
- ISSN :
- 14230399
- Volume :
- 96
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Urologia internationalis
- Accession number :
- edsair.doi.dedup.....98f2ca3f9456f9ea4424bb5fee4d1e4e