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Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

Authors :
Peng Xiao
Shengchao Guo
Xin Wen
Qing-Tao He
Hui Lin
Shen-Ming Huang
Lu Gou
Chao Zhang
Zhao Yang
Ya-Ni Zhong
Chuan-Cheng Yang
Yu Li
Zheng Gong
Xiao-Na Tao
Zhi-Shuai Yang
Yan Lu
Shao-Long Li
Jun-Yan He
Chuanxin Wang
Lei Zhang
Liangliang Kong
Jin-Peng Sun
Xiao Yu
Source :
Nature. 604:771-778
Publication Year :
2022
Publisher :
Springer Science and Business Media LLC, 2022.

Abstract

Adhesion G protein-coupled receptors (aGPCRs) constitute an evolutionarily ancient family of receptors that often undergo autoproteolysis to produce α and β subunits

Details

ISSN :
14764687 and 00280836
Volume :
604
Database :
OpenAIRE
Journal :
Nature
Accession number :
edsair.doi.dedup.....98f7baca07cc2acca9b4479c9b8213dc