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The non-invasive documentation of coronary microcirculation impairment: role of transthoracic echocardiography
- Source :
- Cardiovascular Ultrasound, Cardiovascular Ultrasound, Vol 3, Iss 1, p 18 (2005)
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- Transthoracic Doppler echocardiographic-derived coronary flow reserve is an useful hemodynamic index to assess dysfunction of coronary microcirculation. Isolated coronary microvascular abnormalities are overt by reduced coronary flow reserve despite normal epicardial coronary arteries. These abnormalities may occur in several diseases (arterial hypertension, diabetes mellitus, hypercholesterolemia, syndrome X, aortic valve disease, hypertrophic cardiomyopathy and idiopathic dilated cardiomyopathy). The prognostic role of impaired microvascular coronary flow reserve has been shown unfavourable especially in hypertrophic or idiopathic dilated cardiomyopathies. Coronary flow reserve reduction may be reversible, for instance after regression of left ventricular hypertrophy subsequent to valve replacement in patients with aortic stenosis, after anti-hypertensive treatment or using cholesterol lowering drugs. Coronary flow reserve may increase by 30% or more after pharmacological therapy and achieve normal level >3.0. In contrast to other non invasive tools as positron emission tomography, very expensive and associated with radiation exposure, transthoracic Doppler-derived coronary flow reserve is equally non invasive but cheaper, very accessible and prone to a reliable exploration of coronary microvascular territories, otherwise not detectable by invasive coronary angiography, able to visualize only large epicardial arteries.
- Subjects :
- lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
medicine.medical_treatment
Coronary Disease
Review
Left ventricular hypertrophy
Coronary circulation
Valve replacement
Coronary Circulation
Internal medicine
Image Interpretation, Computer-Assisted
Idiopathic dilated cardiomyopathy
medicine
Humans
Radiology, Nuclear Medicine and imaging
Practice Patterns, Physicians'
Angiology
Clinical Trials as Topic
business.industry
Microcirculation
Medicine (all)
Hypertrophic cardiomyopathy
Coronary flow reserve
General Medicine
medicine.disease
Coronary arteries
medicine.anatomical_structure
lcsh:RC666-701
Radiology Nuclear Medicine and imaging
Echocardiography
Cardiology
Radiology
Cardiology and Cardiovascular Medicine
business
Human
Subjects
Details
- ISSN :
- 14767120
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Ultrasound
- Accession number :
- edsair.doi.dedup.....9905dacb62f79c9b2dfed9415fb4a13a