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A standard calculation methodology for human doubly labeled water studies
- Source :
- Cell reports. Medicine, vol. 2, no. 2, pp. 100203, Cell reports. Medicine, vol 2, iss 2, Cell Reports Medicine, Cell Reports Medicine, Cell Press, 2021, 2 (2), pp.100203. ⟨10.1016/j.xcrm.2021.100203⟩, Speakman, J R, Yamada, Y, Sagayama, H, Sjödin, A M & the IAEA DLW database group 2021, ' A standard calculation methodology for human doubly labeled water studies ', Cell Reports Medicine, vol. 2, no. 2, 100203 . https://doi.org/10.1016/j.xcrm.2021.100203, Cell Reports Medicine, 2(2):100203. Cell Press, Cell Reports. Medicine, 2(2):100203. Cell Press
- Publication Year :
- 2021
-
Abstract
- Summary The doubly labeled water (DLW) method measures total energy expenditure (TEE) in free-living subjects. Several equations are used to convert isotopic data into TEE. Using the International Atomic Energy Agency (IAEA) DLW database (5,756 measurements of adults and children), we show considerable variability is introduced by different equations. The estimated rCO2 is sensitive to the dilution space ratio (DSR) of the two isotopes. Based on performance in validation studies, we propose a new equation based on a new estimate of the mean DSR. The DSR is lower at low body masses (<br />Graphical Abstract<br />Highlights 5,756 doubly labeled water (DLW) measures highlight variation from calculation equation We derive here new equations for calculating CO2 production when using DLW These equations outperform previous equations in validation studies We recommend these equations should be adopted in future studies using DLW in humans<br />Speakman et al. use a large database of doubly labeled water measurements to show the choice of equation for the calculation of energy expenditure introduces significant variation into the final estimate. They then derive new equations that outperform previous equations in validation studies against chamber calorimetry.
- Subjects :
- Indirect
Future studies
BODY-WATER
030309 nutrition & dietetics
[SDV]Life Sciences [q-bio]
Body water
INFANTS
030209 endocrinology & metabolism
Doubly labeled water
total energy expenditure
Carbon dioxide production
Calorimetry
Oxygen Isotopes
Article
General Biochemistry, Genetics and Molecular Biology
RC1200
03 medical and health sciences
0302 clinical medicine
Total energy expenditure
doubly labeled water
free-living
validation
Statistics
INDIRECT CALORIMETRY
Range (statistics)
O-18
Humans
Obesity
(H2O)-H-2-O-18 METHOD
CARBON-DIOXIDE PRODUCTION
ComputingMilieux_MISCELLANEOUS
Mathematics
CO2 PRODUCTION
H-2
0303 health sciences
DILUTION SPACE RATIO
ENERGY-EXPENDITURE
Water
Calorimetry, Indirect
Deuterium
6. Clean water
Dilution
IAEA DLW database group
Body Composition
1182 Biochemistry, cell and molecular biology
Energy Metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 26663791
- Database :
- OpenAIRE
- Journal :
- Cell reports. Medicine, vol. 2, no. 2, pp. 100203, Cell reports. Medicine, vol 2, iss 2, Cell Reports Medicine, Cell Reports Medicine, Cell Press, 2021, 2 (2), pp.100203. ⟨10.1016/j.xcrm.2021.100203⟩, Speakman, J R, Yamada, Y, Sagayama, H, Sjödin, A M & the IAEA DLW database group 2021, ' A standard calculation methodology for human doubly labeled water studies ', Cell Reports Medicine, vol. 2, no. 2, 100203 . https://doi.org/10.1016/j.xcrm.2021.100203, Cell Reports Medicine, 2(2):100203. Cell Press, Cell Reports. Medicine, 2(2):100203. Cell Press
- Accession number :
- edsair.doi.dedup.....991228f1193c0d914ed7ff1151cd31cb