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International consensus for a definition of disease flare in lupus

Authors :
N, Ruperto
L M, Hanrahan
G S, Alarcón
H M, Belmont
R L, Brey
P, Brunetta
J P, Buyon
M I, Costner
M E, Cronin
M A, Dooley
G, Filocamo
D, Fiorentino
P R, Fortin
A G, Franks
G, Gilkeson
E, Ginzler
C, Gordon
J, Grossman
B, Hahn
D A, Isenberg
K C, Kalunian
M, Petri
L, Sammaritano
J, Sánchez-Guerrero
R D, Sontheimer
V, Strand
M, Urowitz
J M, von Feldt
V P, Werth
J T, Merrill
Asad A, Zoma
Source :
Lupus. 20:453-462
Publication Year :
2010
Publisher :
SAGE Publications, 2010.

Abstract

The Lupus Foundation of America (LFA) convened an international working group to obtain a consensus definition of disease flare in lupus. With help from the Paediatric Rheumatology International Trials Organization (PRINTO), two web-based Delphi surveys of physicians were conducted. Subsequently, the LFA held a second consensus conference followed by a third Delphi survey to reach a community-wide agreement for flare definition. Sixty-nine of the 120 (57.5%) polled physicians responded to the first survey. Fifty-nine of the responses were available to draft 12 preliminary statements, which were circulated in the second survey. Eighty-seven of 118 (74%) physicians completed the second survey, with an agreement of 70% for 9/12 (75%) statements. During the second conference, three alternative flare definitions were consolidated and sent back to the international community. One hundred and sixteen of 146 (79.5%) responded, with agreement by 71/116 (61%) for the following definition: “A flare is a measurable increase in disease activity in one or more organ systems involving new or worse clinical signs and symptoms and/or laboratory measurements. It must be considered clinically significant by the assessor and usually there would be at least consideration of a change or an increase in treatment.” The LFA proposes this definition for lupus flare on the basis of its high face validity.

Details

ISSN :
14770962 and 09612033
Volume :
20
Database :
OpenAIRE
Journal :
Lupus
Accession number :
edsair.doi.dedup.....99151cc15f8228b0ae7566ef672fc033
Full Text :
https://doi.org/10.1177/0961203310388445