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Serological TK1 predict pre-cancer in routine health screenings of 56,178 people
- Source :
- Cancer Biomarkers. 22:237-247
- Publication Year :
- 2018
- Publisher :
- IOS Press, 2018.
-
Abstract
- Background People with biomarkers above cut-off values normally have higher risk to develop pre-malignancies and malignancies. Objective Here we investigate if serological TK1 protein (STK1p), AFP, CEA and PSA below cut-off values predict development of pre-cancer. Methods The mean values and the concentration distribution of STK1p, AFP, CEA and PSA were determined in a cohort of 56,178 persons participating a health screening group, consist of people with non-tumor diseases, pre-malignancy and diseases associated with the risk process of malignancy. A health disease-free group (n= 428) was selected among the 56,178 participants and used as controls. Results The STK1p below cut-off value (⩽ 2 pM) showed partly (51.6%) an almost normal concentration distribution and partly (43.9%) an extensive tail in the health screening group, which was not found in the disease-free group. Due to the extensive tail in the distribution, the mean value of STK1p increased significantly (p= 0.0001) from 0.38 ± 0.30 pM in the health disease-free group to 0.69 ± 0.55 pM in the group below the cut-off value. No significantly differences in the concentration distribution and the mean values among gender and ages were observed. On the other hand, there were no difference in the concentration distributions and the mean values of AFP, CEA and PSA between the health disease - free group and the group below cut-off values, as well as between gender and ages. Of interest, the elevated mean value of STK1p of the group below the cut-off value was correlated to pre-malignancy and diseases associated with the risk process of malignancy in liver and prostate. No such correlations were found with AFP, CEA and PSA. Conclusion STK1p is a potential proliferating biomarker for early discover of persons in the risk to develop or already have pre-malignancies or diseases associated with the risk process of malignancy.
- Subjects :
- Adult
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Disease
Malignancy
Thymidine Kinase
Serology
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk process
Prostate
Neoplasms
Internal medicine
Biomarkers, Tumor
Genetics
medicine
Humans
Mass Screening
Early Detection of Cancer
Aged
Retrospective Studies
business.industry
Cancer
General Medicine
Middle Aged
Prognosis
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Oncology
Population Surveillance
030220 oncology & carcinogenesis
Cohort
Biomarker (medicine)
Female
business
Precancerous Conditions
Subjects
Details
- ISSN :
- 18758592 and 15740153
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Cancer Biomarkers
- Accession number :
- edsair.doi.dedup.....9920f4c5cd0f9cd301cda5ddd67da060