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Iron Homeostasis Disorder and Alzheimer's Disease
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 12442, p 12442 (2021)
- Publication Year :
- 2021
-
Abstract
- Iron is an essential trace metal for almost all organisms, including human; however, oxidative stress can easily be caused when iron is in excess, producing toxicity to the human body due to its capability to be both an electron donor and an electron acceptor. Although there is a strict regulation mechanism for iron homeostasis in the human body and brain, it is usually inevitably disturbed by genetic and environmental factors, or disordered with aging, which leads to iron metabolism diseases, including many neurodegenerative diseases such as Alzheimer’s disease (AD). AD is one of the most common degenerative diseases of the central nervous system (CNS) threatening human health. However, the precise pathogenesis of AD is still unclear, which seriously restricts the design of interventions and treatment drugs based on the pathogenesis of AD. Many studies have observed abnormal iron accumulation in different regions of the AD brain, resulting in cognitive, memory, motor and other nerve damages. Understanding the metabolic balance mechanism of iron in the brain is crucial for the treatment of AD, which would provide new cures for the disease. This paper reviews the recent progress in the relationship between iron and AD from the aspects of iron absorption in intestinal cells, storage and regulation of iron in cells and organs, especially for the regulation of iron homeostasis in the human brain and prospects the future directions for AD treatments.
- Subjects :
- genetic intervention
Disease
Review
medicine.disease_cause
Pathogenesis
Human health
Iron homeostasis
Medicine
Homeostasis
oxidative stress
tau
Biology (General)
Cation Transport Proteins
Spectroscopy
β-amyloid
pathogenesis
Transferrin
Brain
General Medicine
Human brain
Computer Science Applications
Chemistry
medicine.anatomical_structure
Liver
Alzheimer’s disease
iron homeostasis regulators
Iron Overload
QH301-705.5
Iron
Central nervous system
Catalysis
Inorganic Chemistry
Alzheimer Disease
Antigens, CD
Receptors, Transferrin
Humans
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Amyloid beta-Peptides
business.industry
Mechanism (biology)
Macrophages
Organic Chemistry
Transfusion Reaction
iron homeostasis disorder
central nervous system
Gene Expression Regulation
Intestinal Absorption
Hepatocytes
business
APP
Neuroscience
Oxidative stress
Transcription Factors
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....993acb955ebf93615873ec6cd4dd9819