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Determining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease
- Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Clinical infectious diseases, 67(12), 1824-1830. Oxford University Press
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- Background The World Health Organization recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons ≥6 months to 45 years residing in typhoid fever (TF)–endemic areas. We now need to consider how TCVs can have the greatest impact in the most vulnerable populations. Methods The Typhoid Fever Surveillance in Africa Program (TSAP) was a blood culture-based surveillance of febrile patients from defined populations presenting at healthcare facilities in 10 African countries. TF and invasive non-typhoidal Salmonella (iNTS) disease incidences were estimated for 0–10 year-olds in one-year age increments. Results Salmonella Typhi and iNTS were the most frequently isolated pathogens; 135 and 94 cases were identified, respectively. Analysis from three countries was excluded (incomplete person-years of observation (PYO) data). Thirty-seven of 123 TF cases (30.1%) and 71/90 iNTS disease cases (78.9%) occurred in children aged<br />A significant burden of typhoid fever in children aged
- Subjects :
- Adult
Vaccines, Conjugate
Adolescent
Fever
iNTS disease
Incidence
Typhoid-Paratyphoid Vaccines
Infant, Newborn
Infant
Salmonella typhi
immunization
Young Adult
Cost of Illness
Salmonella
Child, Preschool
Epidemiological Monitoring
Salmonella Infections
Humans
typhoid conjugate vaccine
Child
Articles and Commentaries
Africa South of the Sahara
Subjects
Details
- ISSN :
- 10584838
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Clinical infectious diseases, 67(12), 1824-1830. Oxford University Press
- Accession number :
- edsair.doi.dedup.....9947fa5468c6a64d48017e604ff71109