NUCLEAR GLYCELALDEHYDE-3-PHOSPHATE DEHYDROGENASE SIGNALING MEDIATES PATHOLOGICAL CARDIAC HYPERTROPHY VIA P300 AND MYOCYTE ENHANCER FACTOR 2

Authors :: Dong Ik Lee
Norimichi Koitabashi
Barbara S. Slusher
Neelam Shahani
Carlos Tristan
Tsuyoshi Tsujimura
Eiki Takimoto
Hanna Jaaro-Peled
David A. Kass
Toshiaki Saitoh
Hideyuki Sasaki
Taro Kariya
Manling Zhang
Yukihiro Tsuchiya
Kyoji Taguchi
Yoshie Horiguchi
Akira Sawa
Guangshuo Zhu
Source :: Journal of the American College of Cardiology. (10):A2153
Publisher :: American College of Cardiology Foundation. Published by Elsevier Inc.
Abstract: Pathologic stressors disrupt cellular homeostasis and cause various diseases, mediated by stress-responsive epigenetic gene regulatory mechanism. Glycelaldehyde-3-phosphate dehydrogenase (GAPDH) is a classic cytosolic glycolytic enzyme, but has been shown to translocate to the nucleus under stress

Subjects :: chemistry.chemical_classification
biology
business.industry
Cellular homeostasis
Dehydrogenase
Cell biology
Cytosol
Enzyme
chemistry
stomatognathic system
biology.protein
Medicine
Glycolysis
Epigenetics
Cardiology and Cardiovascular Medicine
business
Gene
Glyceraldehyde 3-phosphate dehydrogenase

Full Text Access

Tools