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LncRNA CASC15, MiR-23b Cluster and SMAD3 form a Novel Positive Feedback Loop to promote Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer
- Source :
- International Journal of Biological Sciences. 18:1989-2002
- Publication Year :
- 2022
- Publisher :
- Ivyspring International Publisher, 2022.
-
Abstract
- Cancer Susceptibility Candidate 15 (CASC15), which is a newly identified long noncoding RNA crucial for epigenetic regulation in human tumors, was found to be associated with poor prognosis of the patients with ovarian cancer by utilizing The Cancer Genome Atlas and Gene Expression Omnibus database. Therefore, the purpose of this paper was to explore the functional role and latent molecular mechanism of CASC15 in the progression of ovarian cancer.
- Subjects :
- Feedback, Physiological
Ovarian Neoplasms
Epithelial-Mesenchymal Transition
Carcinogenesis
Cell Biology
Applied Microbiology and Biotechnology
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
MicroRNAs
Cell Line, Tumor
Humans
Female
RNA, Long Noncoding
Smad3 Protein
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Cell Proliferation
Developmental Biology
Subjects
Details
- ISSN :
- 14492288
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Sciences
- Accession number :
- edsair.doi.dedup.....9956bc4a5b6c9840937cc75f68e5dce1