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Antifertility Activity ofQuassia amara: Quassin Inhibits the Steroidogenesis in Rat Leydig CellsIn Vitro

Authors :
Joseph I. Okogun
Vincent C. O. Njar
Ebere U. Nduka
Taiwo O. Alao
Adeyombo F. Bolarinwa
Yinusa Raji
Source :
Planta Medica. 61:180-182
Publication Year :
1995
Publisher :
Georg Thieme Verlag KG, 1995.

Abstract

The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.

Details

ISSN :
14390221 and 00320943
Volume :
61
Database :
OpenAIRE
Journal :
Planta Medica
Accession number :
edsair.doi.dedup.....995f51a5eec37237c1e56bb2d4aee635
Full Text :
https://doi.org/10.1055/s-2006-958044