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Health-related quality of life outcomes in HIV-infected patients starting different combination regimens in a randomized multinational trial: the INITIO-QoL substudy
- Source :
- AIDS research and human retroviruses. 23(10)
- Publication Year :
- 2007
-
Abstract
- The health-related quality of life (HRQoL) outcomes in HIV-infected, treatment-naive patients starting different HAART regimens in a 3-year, randomized, multinational trial were compared. HRQoL was measured in a subgroup of patients enrolled in the INITIO study (153/911), using a modified version of the MOS-HIV questionnaire. The regimens compared in the INITIO trial were composed by two NRTIs (didanosine + stavudine) plus either an NNRTI (efavirenz) or a PI (nelfinavir), or both (efavirenz + nelfinavir). Primary HRQoL outcomes were Physical and Mental Health Summary scores (PHS and MHS, respectively). During follow-up, an increase of PHS score was observed in all treatment arms. The MHS score remained substantially unchanged with the four-drug combination and showed with both NNRTI- and PI-based three-drug regimens a marked trend toward improvement, which became statistically significant when a multiple imputation method was used to adjust for missing data. Overall, starting all the combination regimens compared in the INITIO study was associated with a maintained or slightly improved HRQOL status, consistently with the positive immunological and virological changes observed in the main study. The observed differences in the MHS indicate a possible HRQoL benefit associated to the use of three-drug, two-class regimens and no additional benefit for the use of four-drug, three-class regimens, confirming that three-drug, two-class regimens that include two NRTIs plus either an NNRTI or a PI should be preferred as initial treatment of HIV infection.
- Subjects :
- Adult
Male
medicine.medical_specialty
Efavirenz
Anti-HIV Agents
Immunology
HIV Infections
chemistry.chemical_compound
Quality of life
Acquired immunodeficiency syndrome (AIDS)
Clinical Protocols
immune system diseases
Virology
Internal medicine
Immunopathology
Antiretroviral Therapy, Highly Active
Surveys and Questionnaires
medicine
Humans
Sida
Didanosine
biology
business.industry
Stavudine
virus diseases
Middle Aged
medicine.disease
biology.organism_classification
Surgery
Infectious Diseases
Nelfinavir
Mental Health
chemistry
Physical Fitness
Quality of Life
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 08892229
- Volume :
- 23
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- AIDS research and human retroviruses
- Accession number :
- edsair.doi.dedup.....9970c58e65c455bfea881d554be04010