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Anorexia Nervosa and Osteoporosis
- Source :
- Calcified Tissue International. 110:562-575
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Patients with anorexia nervosa (AN) often experience low bone mineral density (BMD) and increased fracture risk, with low body weight and decreased gonadal function being the strongest predictors of the observed bone mineral deficit and fractures. Other metabolic disturbances have also been linked to bone loss in this group of patients, including growth hormone resistance, low insulin-like growth factor-1 (IGF-1) concentrations, low leptin concentrations, and hypercortisolemia. However, these correlations lack definitive evidence of causality. Weight restoration and resumption of menstrual function have the strongest impact on increasing BMD. Other potential treatment options include bisphosphonates and teriparatide, supported by data from small clinical trials, but these agents are not approved for the treatment of low BMD in adolescents or premenopausal women with AN.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Anorexia Nervosa
Adolescent
Endocrinology, Diabetes and Metabolism
Osteoporosis
Physiology
030209 endocrinology & metabolism
Fractures, Bone
03 medical and health sciences
0302 clinical medicine
Endocrinology
Bone Density
Teriparatide
Humans
Medicine
Orthopedics and Sports Medicine
Bone mineral
Diphosphonates
business.industry
Leptin
medicine.disease
Clinical trial
Bone Diseases, Metabolic
Hypercortisolemia
Anorexia nervosa (differential diagnoses)
Orthopedic surgery
Female
030101 anatomy & morphology
business
medicine.drug
Subjects
Details
- ISSN :
- 14320827
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Calcified Tissue International
- Accession number :
- edsair.doi.dedup.....9974467e2be2e58c60f55acd0d53fbcd