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Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors
- Source :
- Chemistry & Biodiversity. 19
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- A series of novel quinazolinone hydrazide derivatives were designed and synthesized as EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti-tumor cell proliferation and EGFR inhibitory activities. In the comprehensive analysis of all the tested compounds, the target compound 9c showed the best anti-tumor cell proliferation activity, (IC
- Subjects :
- Molecular Structure
Antineoplastic Agents
Bioengineering
General Chemistry
General Medicine
Biochemistry
ErbB Receptors
Molecular Docking Simulation
Structure-Activity Relationship
Hydrazines
Drug Design
Neoplasms
Humans
Molecular Medicine
Drug Screening Assays, Antitumor
Protein Kinase Inhibitors
Molecular Biology
Quinazolinones
Subjects
Details
- ISSN :
- 16121880 and 16121872
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Chemistry & Biodiversity
- Accession number :
- edsair.doi.dedup.....99aa32f248258e4c0027278113b606d2