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CHARACTERIZATION OF DEMENTIA WITH LEWY BODIES (DLB) AND MILD COGNITIVE IMPAIRMENT USING THE LEWY BODY DEMENTIA MODULE (LBD-MOD)
- Source :
- Alzheimers Dement
- Publication Year :
- 2021
-
Abstract
- Introduction The National Institute on Aging Alzheimer's Disease Research Center program added the Lewy body dementia module (LBD-MOD) to the Uniform Data Set to facilitate LBD characterization and distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). We tested the performance of the LBD-MOD. Methods The LBD-MOD was completed in a single-site study in 342 participants: 53 controls, 78 AD, and 110 DLB; 79 mild cognitive impairment due to AD (MCI-AD); and 22 MCI-DLB. Results DLB differed from AD in extrapyramidal symptoms, hallucinations, apathy, autonomic features, REM sleep behaviors, daytime sleepiness, cognitive fluctuations, timed attention tasks, and visual perception. MCI-DLB differed from MCI-AD in extrapyramidal features, mood, autonomic features, fluctuations, timed attention tasks, and visual perception. Descriptive data on LBD-MOD measures are provided for reference. Discussion The LBD-MOD provided excellent characterization of core and supportive features to differentiate DLB from AD and healthy controls while also characterizing features of MCI-DLB.
- Subjects :
- Lewy Body Disease
Male
medicine.medical_specialty
Visual perception
Epidemiology
REM Sleep Behavior Disorder
Audiology
Neuropsychological Tests
behavioral disciplines and activities
Article
Diagnosis, Differential
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Developmental Neuroscience
Extrapyramidal symptoms
Parkinsonian Disorders
Alzheimer Disease
mental disorders
medicine
Dementia
Humans
Apathy
Cognitive Dysfunction
Aged
030214 geriatrics
Lewy body
Dementia with Lewy bodies
business.industry
Health Policy
Cognition
medicine.disease
nervous system diseases
Psychiatry and Mental health
Mood
Cross-Sectional Studies
Female
Neurology (clinical)
Geriatrics and Gerontology
medicine.symptom
business
hormones, hormone substitutes, and hormone antagonists
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Alzheimers Dement
- Accession number :
- edsair.doi.dedup.....99ab2d41df3d1b8bf0de4a4dc37877c9