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Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial
Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double‐blind, randomized controlled trial
- Source :
- Phytotherapy Research. 34:340-348
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Codonopsis lanceolata (CL) extract was shown to have antihypertensive effects in hypertensive rats. This randomized controlled trial was designed to investigate the ability of CL extract to prevent hypertension (HTN) in prehypertensive subjects. Eighty subjects aged 19-60 years with a systolic blood pressure (BP) of 120-139 mmHg and a diastolic BP of 80-89 mmHg were recruited over 3 months. Subjects were randomized 1:1 to a CL group and a placebo (PL) group and administered CL extract and starch, respectively, for 6 weeks. (BP) was measured and blood sampled at baseline and at the end of the trial. Relative to baseline, systolic BP was significantly decreased, and catalase activity was significantly increased following CL treatment in both the elevated systolic BP and stage 1 HTN subgroups. In the elevated systolic BP subgroup, serum nitrite concentration relative to baseline was significantly increased in CL compared to PL treated subjects (p = .038). In subjects with stage 1 HTN, high sensitivity C-reactive protein (p = .020) and malondialdehyde (p = .039) showed significantly greater reductions from baseline in the CL than in the PL group. In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.
- Subjects :
- Adult
Male
medicine.medical_specialty
Diastole
Blood Pressure
Placebo
Gastroenterology
Prehypertension
law.invention
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Double-Blind Method
Randomized controlled trial
law
Malondialdehyde
Internal medicine
medicine
Humans
Codonopsis lanceolata
Endothelial dysfunction
Antihypertensive Agents
Nitrites
Pharmacology
Codonopsis
0303 health sciences
biology
Plant Extracts
business.industry
030302 biochemistry & molecular biology
Middle Aged
medicine.disease
biology.organism_classification
C-Reactive Protein
Blood pressure
chemistry
030220 oncology & carcinogenesis
Female
Lipid Peroxidation
business
Subjects
Details
- ISSN :
- 10991573 and 0951418X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Phytotherapy Research
- Accession number :
- edsair.doi.dedup.....99c9f5ceeff381266d139b4be97213ab
- Full Text :
- https://doi.org/10.1002/ptr.6520