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Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology
- Source :
- Cardiovasc Res, Cardiovascular Research, 115(9), 1385-1392. Oxford University Press, Cardiovascular research, 115(9), 1385-1392. Oxford University Press, Cardiovascular Research, Ketelhuth, D F J, Lutgens, E, Bäck, M, Binder, C J, Van den Bossche, J, Daniel, C, Dumitriu, I E, Hoefer, I, Libby, P, O'Neill, L, Weber, C & Evans, P C 2019, ' Immunometabolism and atherosclerosis : perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology ', Cardiovascular Research, vol. 115, no. 9, pp. 1385-1392 . https://doi.org/10.1093/cvr/cvz166
- Publication Year :
- 2018
-
Abstract
- Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.
- Subjects :
- 0301 basic medicine
Physiology
MACROPHAGE IMMUNOMETABOLISM
T-Lymphocytes
Macrophages/immunology
Disease
030204 cardiovascular system & hematology
Bioinformatics
Monocytes
0302 clinical medicine
IMMUNE-RESPONSE
INDUCTION
Vascular biology
Position Paper from European Society of Cardiology Working Group
Arteries
Inflammation/immunology
Plaque, Atherosclerotic
3. Good health
TRIMETHYLAMINE N-OXIDE
medicine.symptom
Inflammation Mediators
Cardiology and Cardiovascular Medicine
Atherosclerosis/immunology
medicine.drug
Signal Transduction
Consensus
IMAGING ATHEROSCLEROSIS
Inflammation
METABOLISM
DENDRITIC CELLS
Immunomodulation
03 medical and health sciences
Immune system
Immunity
Vascular
Physiology (medical)
medicine
Animals
Humans
Inflammation Mediators/immunology
Clinical significance
REGULATORY T-CELLS
business.industry
Macrophages
Arteries/immunology
GLUTAMINE UPTAKE
Monocytes/immunology
T-Lymphocytes/immunology
Atherosclerosis
Canakinumab
030104 developmental biology
Immune System
Position paper
Energy Metabolism/immunology
Immune System/immunology
business
Energy Metabolism
Subjects
Details
- ISSN :
- 17553245 and 00086363
- Volume :
- 115
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Cardiovascular research
- Accession number :
- edsair.doi.dedup.....99ca1284315b8e24567fdc2ee10cd700