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A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α
A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α
- Source :
- Cancer Biology & Therapy
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- Hypoxia is a general event in solid tumor growth. Therefore, induced cellular responses by hypoxia are important for tumorigenesis and tumor growth. MicroRNAs (miRNAs) have recently emerged as important regulators of hypoxia induced cellular responses. Here we report that miR-147a is a novel and crucial hypoxia induced miRNA. HIF-1α up-regulates the expression of miR-147a, and miR-147a in turn stabilizes and accumulates HIF-1α protein via directly targeting HIF-3α, a dominant negative regulator of HIF-1α. Subsequent studies in xenograft mouse model reveal that miR-147a is capable of inhibiting tumor growth. Collectively, these data demonstrate a positive feedback loop between HIF-1α, miR-147a and HIF-3α, which provide a new insight into the mechanism of miR-147a induced cell proliferation arrest under hypoxia.
- Subjects :
- Male
0301 basic medicine
Cancer Research
Regulator
Dominant negative
Mice, Nude
HIF-1α
Apoptosis
Biology
Transfection
medicine.disease_cause
Mice
03 medical and health sciences
miR-147a
HIF-3α
microRNA
medicine
Animals
Humans
Tumor growth
Amino Acid Sequence
Cell proliferation
Positive feedback
Pharmacology
Mice, Inbred BALB C
Cell growth
Hypoxia (medical)
Hypoxia-Inducible Factor 1, alpha Subunit
Cell Hypoxia
Up-Regulation
Cell biology
MicroRNAs
030104 developmental biology
Oncology
Heterografts
Molecular Medicine
medicine.symptom
Carcinogenesis
HeLa Cells
Research Paper
Subjects
Details
- ISSN :
- 15558576 and 15384047
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Cancer Biology & Therapy
- Accession number :
- edsair.doi.dedup.....9a04156a8ebc07850071ab53ddeae2b9
- Full Text :
- https://doi.org/10.1080/15384047.2016.1195040