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A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α

A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α

Authors :
Yaou Zhang
Caiming Tian
Nunu Huang
Naihan Xu
Fan Wang
Anlin Ye
Haoxiang Zhang
Guangnan Hu
Jie He
Source :
Cancer Biology & Therapy
Publication Year :
2016
Publisher :
Informa UK Limited, 2016.

Abstract

Hypoxia is a general event in solid tumor growth. Therefore, induced cellular responses by hypoxia are important for tumorigenesis and tumor growth. MicroRNAs (miRNAs) have recently emerged as important regulators of hypoxia induced cellular responses. Here we report that miR-147a is a novel and crucial hypoxia induced miRNA. HIF-1α up-regulates the expression of miR-147a, and miR-147a in turn stabilizes and accumulates HIF-1α protein via directly targeting HIF-3α, a dominant negative regulator of HIF-1α. Subsequent studies in xenograft mouse model reveal that miR-147a is capable of inhibiting tumor growth. Collectively, these data demonstrate a positive feedback loop between HIF-1α, miR-147a and HIF-3α, which provide a new insight into the mechanism of miR-147a induced cell proliferation arrest under hypoxia.

Details

ISSN :
15558576 and 15384047
Volume :
17
Database :
OpenAIRE
Journal :
Cancer Biology & Therapy
Accession number :
edsair.doi.dedup.....9a04156a8ebc07850071ab53ddeae2b9
Full Text :
https://doi.org/10.1080/15384047.2016.1195040