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Usefulness of the log odds of positive lymph nodes to predict and discriminate prognosis in gastric carcinomas
- Source :
- JOURNAL OF GASTROINTESTINAL SURGERY, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, instname, r-FISABIO. Repositorio Institucional de Producción Científica, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Publication Year :
- 2015
- Publisher :
- Springer Verlag, 2015.
-
Abstract
- The lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) have been proposed to minimize the stage migration phenomenon. The value of the LODDS and LNR staging systems to predict and discriminate prognosis was assessed and compared to the International Union Against Cancer (UICC) TNM classification (pN). Three hundred and twenty-six patients with gastric carcinoma were retrospectively studied. Disease-specific survival rates were calculated for every pN, LNR, and LODDS category. Four LNR categories (0, 1-25, 26-75, and > 76 %) and four LODDS categories (-5 to -3, > -3 to -1, > -1 to 3, and > 3 to 5) were established. In the multivariate analysis, only the stage pT3-4 versus pT1-2 (HR 1.88, 95 % CI 1.11-3.20, p = 0.02) and LODDS as continuous variable (HR 1.40, 95 % CI 1.21-1.61, p < 0.001) remained as independent prognostic factors. In patients with < 16 lymph nodes retrieved, only the LODDS system could discriminate different disease-specific survival curves for every category. LODDS categories were able to discriminate subgroups with different prognoses in pN stages and LNR categories. The LODDS staging system was superior to the pN classification and LNR system to discriminate risk prognosis especially in patients with an insufficient number of retrieved lymph nodes.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Multivariate analysis
LODDS
education
Lymph node ratio
Gastrectomy
Stomach Neoplasms
Internal medicine
Lymphnodes
medicine
Humans
Stage (cooking)
Survival rate
Lymph node
Survival analysis
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
business.industry
Gastroenterology
Cancer
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
digestive system diseases
Survival Rate
medicine.anatomical_structure
Female
Surgery
Lymph Nodes
Lymph
Gastric cancer
business
Subjects
Details
- ISSN :
- 1091255X
- Database :
- OpenAIRE
- Journal :
- JOURNAL OF GASTROINTESTINAL SURGERY, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, instname, r-FISABIO. Repositorio Institucional de Producción Científica, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
- Accession number :
- edsair.doi.dedup.....9a16e7c5fd827b6d03bdb705608298ac