Back to Search
Start Over
Impact of Steroid Only Induction on Rejection in Simultaneous Liver-Kidney Transplantation
- Source :
- Progress in Transplantation. 32:363-369
- Publication Year :
- 2022
- Publisher :
- SAGE Publications, 2022.
-
Abstract
- Introduction: The occurrence of simultaneous liver kidney transplantation has greatly increased; however, the ideal induction and maintenance immunosuppression remains unknown. Question: This evaluation aimed to determine if corticosteroid only induction in simultaneous liver kidney transplant recipients provided adequate prophylaxis against rejection when compared to basiliximab. Design: This was a single center, retrospective, cohort study of adult simultaneous liver kidney transplant recipients from June 2010 to June 2019 receiving corticosteroid only (N = 41) or basiliximab (N = 42) induction. Results: Liver or kidney biopsy proven acute rejection at 3 months was comparable between the corticosteroid only and basiliximab groups (10% vs 7%, P = .67), which persisted through 12 months posttransplant (15% vs 21%, P = .42). The occurrence of any infection at 3 months was increased in the corticosteroid only group relative to the basiliximab group (41% vs 21%, P = .049). Graft and patient survival at 12 months were similar between groups. Maintenance immunosuppression was overall minimized with a tacrolimus goal of 6-8 ng/mL, mycophenolate mofetil dose reduction to 1000 mg/day by 3 months, and early steroid withdrawal in both groups. Conclusion: Our findings suggested that corticosteroid only induction was an effective strategy for preventing rejection in simultaneous liver kidney transplant recipients, even in combination with reduced maintenance immunosuppression.
Details
- ISSN :
- 21646708 and 15269248
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Progress in Transplantation
- Accession number :
- edsair.doi.dedup.....9a22a15c5bd6f8891bc9dc5c1be9da3e