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Understanding the microbiome: a primer on the role of the microbiome in colorectal neoplasia
- Source :
- Annals of Gastroenterology
- Publication Year :
- 2020
- Publisher :
- Hellenic Society of Gastroenterology, 2020.
-
Abstract
- Colorectal cancer is a leading cause of cancer-related death internationally, with mounting evidence pointing to the role of the microbiome in adenoma and cancer development. This article aims to provide clinicians with a foundation for understanding the field of research into the microbiome. We also illustrate the various ways in which the microbiota have been linked to colorectal cancer, with a specific focus on microbiota with identified virulence factors, and also on the ways that byproducts of microbiota metabolism may result in oncogenesis. We also review strategies for manipulating the microbiome for therapeutic effects.
- Subjects :
- 0301 basic medicine
030109 nutrition & dietetics
Colorectal cancer
business.industry
Gastroenterology
colorectal cancer
colorectal adenomas
Review Article
Bioinformatics
medicine.disease
stomatognathic diseases
03 medical and health sciences
0302 clinical medicine
030220 oncology & carcinogenesis
medicine
Microbiome
Cancer development
business
Subjects
Details
- ISSN :
- 17927463
- Database :
- OpenAIRE
- Journal :
- Annals of Gastroenterology
- Accession number :
- edsair.doi.dedup.....9a303abca0346558730fa9a64c85a279