Ingested capsaicinoids can prevent low-fat–high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways

Kazim Sahin,1 Cemal Orhan,1 Mehmet Tuzcu,2 Nurhan Sahin,1 Oguzhan Ozdemir,2 Vijaya Juturu3 1Department of Animal Nutrition, Veterinary Faculty, Firat University, Elazig, Turkey; 2Department of Biology, Faculty of Science, Firat University, Elazig, Turkey; 3Scientific and Clinical Affairs, Research and Development, OmniActive Health Technologies, Inc., Morristown, NJ, USA Objective: Capsaicinoids (CAPs), most commonly found in chili peppers, have a multitude of pharmacological and physiological effects, such as anti-inflammation, antioxidant, and anticancer effects. In the present study, we set out to investigate the hypothesis that CAPs mitigate obesity in rats and the possible mechanisms thereof.Materials and methods: Rats were divided into six groups, including control (±10 mg CAPs/kg body weight [BW]), low-fat–high-sucrose diet (±10 mg CAPs/kg BW), and high-fat diet (±10 mg CAPs/kg BW). Blood samples and liver and aortic tissues were taken at the end of the study.Results: CAPs supplementation significantly reduced hyperglycemia and hyperlipidemia (P