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Effect of breastfeeding on asthma, lung function and bronchial hyperreactivity in ISAAC Phase II
- Source :
- European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2009, 33 (5), pp.993-1002. ⟨10.1183/09031936.00075708⟩, European Respiratory Journal, 2009, 33 (5), pp.993-1002. ⟨10.1183/09031936.00075708⟩
- Publication Year :
- 2009
- Publisher :
- HAL CCSD, 2009.
-
Abstract
- International audience; The association between breastfeeding and wheezing, lung function and atopy was evaluated in the International Study of Asthma and Allergy in Childhood (ISAAC) Phase II. Cross-sectional studies were performed in 27 centres in 20 countries. Information on disease and exposure factors was collected by parental questionnaires. Data from 54,000 randomly selected school children (aged 8-12 yrs, 31,759 with skin prick testing) and a stratified subsample (n = 4,888) were used for testing the correlation of breastfeeding with bronchial hyperreactivity and lung function. Random effect models for meta-analysis were applied to calculate combined odds ratios (ORs). Any breastfeeding was associated with less wheeze both in affluent (adjusted OR (OR(adj)) 0.87, 95% confidence interval (CI) 0.78-0.97) and nonaffluent countries (OR(adj) 0.80, 95% CI 0.68-0.94). Further analyses revealed that this was true only for nonatopic wheeze in nonaffluent countries (OR(adj) 0.69, 95% CI 0.53-0.90). Breastfeeding was not associated with atopic wheeze and objective measures of allergy in both affluent and nonaffluent countries. In contrast, breastfeeding was associated with higher predicted forced expiratory volume in one second in affluent countries only (mean ratio 1.11, 95% CI 1.02-1.20). Breastfeeding is associated with protection against nonatopic wheeze, which becomes particularly evident in nonaffluent countries. Overall, breastfeeding was not related to any measure of allergy. These findings may explain some of the controversy regarding breastfeeding, since the direction of the association with breastfeeding depends on the predominating wheeze phenotype (e.g. atopic, nonatopic).
- Subjects :
- Male
Pediatrics
Time Factors
MESH: Asthma
MESH: Respiratory Sounds
Respiratory System
Breastfeeding
MESH: Logistic Models
MESH: Respiratory Function Tests
Atopy
MESH: Conjunctivitis
0302 clinical medicine
Risk Factors
MESH: Risk Factors
Surveys and Questionnaires
MESH: Child
030212 general & internal medicine
Child
MESH: Rhinitis
Respiratory Function Tests
3. Good health
Breast Feeding
MESH: Breast Feeding
Female
Bronchial Hyperreactivity
medicine.symptom
Pulmonary and Respiratory Medicine
medicine.medical_specialty
MESH: Socioeconomic Factors
MESH: Allergens
MESH: Hypersensitivity
03 medical and health sciences
MESH: Cross-Sectional Studies
MESH: Skin Tests
Wheeze
medicine
Humans
MESH: Prevalence
Respiratory Sounds
Retrospective Studies
Asthma
MESH: Humans
MESH: Rhinitis, Allergic, Perennial
business.industry
MESH: Questionnaires
MESH: Time Factors
MESH: Bronchial Hyperreactivity
MESH: Rhinitis, Allergic, Seasonal
MESH: Retrospective Studies
Odds ratio
medicine.disease
Confidence interval
MESH: Male
Logistic Models
Socioeconomic Factors
030228 respiratory system
El Niño
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
Breast feeding
MESH: Seasons
MESH: Female
MESH: Models, Statistical
Subjects
Details
- Language :
- English
- ISSN :
- 09031936 and 13993003
- Database :
- OpenAIRE
- Journal :
- European Respiratory Journal, European Respiratory Journal, European Respiratory Society, 2009, 33 (5), pp.993-1002. ⟨10.1183/09031936.00075708⟩, European Respiratory Journal, 2009, 33 (5), pp.993-1002. ⟨10.1183/09031936.00075708⟩
- Accession number :
- edsair.doi.dedup.....9a3710f303af20ab1a74a0c18e0ce949