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Systemic evaluation of the relationship between psoriasis, psoriatic arthritis and osteoporosis: observational and mendelian randomization study
- Source :
- Ann Rheum Dis
- Publication Year :
- 2020
-
Abstract
- Objectives and methodsWith 432 513 samples from UK Biobank dataset, multivariable linear/logistic regression were used to estimate the relationship between psoriasis/psoriatic arthritis (PsA) and estimated bone mineral density (eBMD)/osteoporosis, controlling for potential confounders. Here, confounders were set in three ways: model0 (including age, height, weight, smoking and drinking), model1 (model0 +regular physical activity) and model2 (model1 +medication treatments). The eBMD was derived from heel ultrasound measurement. And 4904 patients with psoriasis and 847 patients with PsA were included in final analysis. Mendelian randomisation (MR) approach was used to evaluate the causal effect between them.ResultsLower eBMD were observed in patients with PsA than in controls in both model0 (β-coefficient=−0.014, p=0.0006) and model1 (β-coefficient=−0.013, p=0.002); however, the association disappeared when conditioning on treatment with methotrexate or ciclosporin (model2) (β-coefficient=−0.005, p=0.28), mediation analysis showed that 63% of the intermediary effect on eBMD was mediated by medication treatment (pConclusionsThe effect of PsA on osteoporosis was secondary (eg, medication) but not causal. Under this hypothesis, psoriasis without arthritis was not a risk factor for osteoporosis.
- Subjects :
- 030203 arthritis & rheumatology
0301 basic medicine
medicine.medical_specialty
Bone density
business.industry
Immunology
Osteoporosis
Confounding
Arthritis
medicine.disease
Logistic regression
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
Psoriatic arthritis
030104 developmental biology
0302 clinical medicine
Rheumatology
Psoriasis
Internal medicine
medicine
Immunology and Allergy
Risk factor
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Ann Rheum Dis
- Accession number :
- edsair.doi.dedup.....9a411e6742675bc2e8ee892c22e7e763