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Spatial and temporal tools for building a human cell atlas
- Source :
- Molecular Biology of the Cell
- Publication Year :
- 2019
- Publisher :
- American Society for Cell Biology (ASCB), 2019.
-
Abstract
- Improvements in the sensitivity, content, and throughput of microscopy, in the depth and throughput of single-cell sequencing approaches, and in computational and modeling tools for data integration have created a portfolio of methods for building spatiotemporal cell atlases. Challenges in this fast-moving field include optimizing experimental conditions to allow a holistic view of tissues, extending molecular analysis across multiple timescales, and developing new tools for 1) managing large data sets, 2) extracting patterns and correlation from these data, and 3) integrating and visualizing data and derived results in an informative way. The utility of these tools and atlases for the broader scientific community will be accelerated through a commitment to findable, accessible, interoperable, and reusable data and tool sharing principles that can be facilitated through coordination and collaboration between programs working in this space.
- Subjects :
- Data Analysis
Microscopy
0303 health sciences
Atlas (topology)
Interoperability
Cell Biology
Biology
Human cell
computer.software_genre
Data science
Field (computer science)
Molecular analysis
03 medical and health sciences
Atlases as Topic
0302 clinical medicine
Perspective
Humans
Anatomy, Artistic
Molecular Biology
Throughput (business)
computer
Data Curation
030217 neurology & neurosurgery
030304 developmental biology
Data integration
Subjects
Details
- ISSN :
- 19394586 and 10591524
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Molecular Biology of the Cell
- Accession number :
- edsair.doi.dedup.....9a5a44a3efb1313213596b6d4aed03aa
- Full Text :
- https://doi.org/10.1091/mbc.e18-10-0667