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Altered Regional Homogeneity and Functional Connectivity during Microlesion Period after Deep Brain Stimulation in Parkinson's Disease
- Source :
- Parkinson's Disease, Parkinson's Disease, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi, 2021.
-
Abstract
- Background. Patients with Parkinson’s disease (PD) undergoing deep brain electrode implantation experience a temporary improvement in motor symptoms before the electrical stimulation begins. We usually call this the microlesion effect (MLE), but the mechanism behind it is not clear. Purpose. This study aimed to assess the alterations in brain functions at the regional and whole-brain levels, using regional homogeneity (ReHo) and functional connectivity (FC), during the postoperative microlesion period after deep brain stimulation (DBS) in PD patients. Method. Resting-state functional MRI data were collected from 27 PD patients before and after the first day of DBS and 12 healthy controls (HCs) in this study. The ReHo in combination with FC analysis was used to investigate the alterations of regional brain activity in all the subjects. Results. There were increased ReHo in the basal ganglia-thalamocortical circuit (left supplementary motor area and bilateral paracentral lobule), whereas decreased ReHo in the default mode network (DMN) (left angular gyrus, bilateral precuneus), prefrontal cortex (bilateral middle frontal gyrus), and the cerebello-thalamocortical (CTC) circuit (Cerebellum_crus2/1_L) after DBS. In addition, we also found abnormal FC in the lingual gyrus, cerebellum, and DMN. Conclusion. Microlesion of the thalamus caused by electrode implantation can alter the activity of the basal ganglia-thalamocortical circuit, prefrontal cortex, DMN, and CTC circuit and induce abnormal FC in the lingual gyrus, cerebellum, prefrontal cortex, and DMN among PD patients. The findings of this study contribute to the understanding of the mechanism of MLE.
- Subjects :
- Deep brain stimulation
Article Subject
Brain activity and meditation
business.industry
medicine.medical_treatment
Neuroscience (miscellaneous)
Precuneus
Lingual gyrus
Psychiatry and Mental health
medicine.anatomical_structure
medicine
Middle frontal gyrus
Neurology (clinical)
Neurology. Diseases of the nervous system
Paracentral lobule
Prefrontal cortex
business
RC346-429
Neuroscience
Default mode network
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20420080 and 20908083
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Parkinson's Disease
- Accession number :
- edsair.doi.dedup.....9a6999a1ea7f838f31284e6051b15701