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A Review of Current Standards and the Evolution of Histopathology Nomenclature for Laboratory Animals
- Publication Year :
- 2018
- Publisher :
- Oxford University Press, 2018.
-
Abstract
- The need for international collaboration in rodent pathology has evolved since the 1970s and was initially driven by the new field of toxicologic pathology. First initiated by the World Health Organization’s International Agency for Research on Cancer for rodents, it has evolved to include pathology of the major species (rats, mice, guinea pigs, nonhuman primates, pigs, dogs, fish, rabbits) used in medical research, safety assessment, and mouse pathology. The collaborative effort today is driven by the needs of the regulatory agencies in multiple countries, and by needs of research involving genetically engineered animals, for “basic” research and for more translational preclinical models of human disease. These efforts led to the establishment of an international rodent pathology nomenclature program. Since that time, multiple collaborations for standardization of laboratory animal pathology nomenclature and diagnostic criteria have been developed, and just a few are described herein. Recently, approaches to a nomenclature that is amenable to sophisticated computation have been made available and implemented for large-scale programs in functional genomics and aging. Most terminologies continue to evolve as the science of human and veterinary pathology continues to develop, but standardization and successful implementation remain critical for scientific communication now as ever in the history of veterinary nosology.
- Subjects :
- 0301 basic medicine
National Toxicology Program Nonneoplastic Lesion Atlas
Biomedical Research
Standardization
Veterinary pathology
Guinea Pigs
Review Article
General Biochemistry, Genetics and Molecular Biology
World health
03 medical and health sciences
Mice
Human disease
Dogs
Animals, Laboratory
Terminology as Topic
Medicine
Animals
Humans
Genetically Engineered Animals
Nomenclature
National Cancer Institute Mouse Models of Human Cancer Consortium
business.industry
General Medicine
International Agency for Research on Cancer
Medical research
Rats
030104 developmental biology
mouse pathology ontology
Animal Science and Zoology
Engineering ethics
International Harmonization of Nomenclature and Diagnostic Criteria
nomenclature
standard for exchange of nonclinical data
Rabbits
International Mouse Phenotyping Consortium
business
International agency
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9a80a1e2c939311b24c4b456e1d9b3d9