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Selective prostaglandin D2 receptor stimulation elicits ocular hypotensive effects in rabbits and cats
- Source :
- European Journal of Pharmacology. 275:245-250
- Publication Year :
- 1995
- Publisher :
- Elsevier BV, 1995.
-
Abstract
- The effects of the selective prostaglandin D2 (DP) receptor agonists, 572C85 ((+/-)-5-(3-carboxypropylthio)-1-(2-cyclohexyl-2-hydroxyethyl- amino)hexahydrocyclopenta(d)imidazol-2(1H)-one) and 192C86 ((+/-)-5-(3-carboxypropylthio)-1-(2-cyclohexyl-2-hydroxyethylidene - amino)-3-ethylhexahydrocyclopenta(d)imidazol-2(1H)-one), were determined on intraocular pressure regulation in rabbits and cats. 572C85 (50 micrograms) in rabbits maximally lowered intraocular pressure by 4.3 mm Hg, and significantly for 4 h compared to control. In cats 572C85 had a similar effect. 192C86 (50 micrograms) reduced intraocular pressure by 2.8 mm Hg for 2 h in rabbits. Following exposure to the specific DP receptor antagonist, BW A868C ((+/-)-3-benzyl-5-(6-carboxyhexyl)-1-(2-cyclohexyl-2-hydroxyethylamin o)- hydantoin; 50 micrograms), which had no effect on intraocular pressure by itself, 572C85 (50 micrograms) did not reduce intraocular pressure in rabbits and cats. The intraocular pressure lowering effect of the mixed DP and EP receptor agonist, BW245C (5-(6-carboxyhexyl)-1-(3-cyclohexyl-3-hydroxypropyl)-hydantoin; 50 micrograms), in cats was suppressed by only 64% by BW A868C (50 micrograms). These results clearly show that the DP receptors in rabbit and cat eyes are involved in intraocular pressure regulation. However, under baseline conditions DP receptor activity does not contribute to this regulation.
- Subjects :
- Male
Agonist
medicine.medical_specialty
Intraocular pressure
medicine.drug_class
Receptors, Prostaglandin
Prostaglandin
chemistry.chemical_compound
Internal medicine
medicine
Animals
Receptors, Immunologic
Receptor
Intraocular Pressure
Prostaglandin D2 receptor
Pharmacology
CATS
biology
Chemistry
Hydantoins
Fissipedia
Imidazoles
biology.organism_classification
Butyrates
Endocrinology
Cats
Rabbits
Prostaglandin D2
Subjects
Details
- ISSN :
- 00142999
- Volume :
- 275
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....9a96d4288700acb5002f81dbc79033b8