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A large-scale standardized physiological survey reveals functional organization of the mouse visual cortex
- Source :
- Nature neuroscience
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- To understand how the brain processes sensory information to guide behavior, we must know how stimulus representations are transformed throughout the visual cortex. Here we report an open, large-scale physiological survey of activity in the awake mouse visual cortex: the Allen Brain Observatory Visual Coding dataset. This publicly available dataset includes the cortical activity of nearly 60,000 neurons from six visual areas, four layers, and 12 transgenic mouse lines in a total of 243 adult mice, in response to a systematic set of visual stimuli. We classify neurons on the basis of joint reliabilities to multiple stimuli and validate this functional classification with models of visual responses. While most classes are characterized by responses to specific subsets of the stimuli, the largest class is not reliably responsive to any of the stimuli and becomes progressively larger in higher visual areas. These classes reveal a functional organization wherein putative dorsal areas show specialization for visual motion signals.
- Subjects :
- 0301 basic medicine
Dorsum
Visual perception
genetic structures
Extramural
General Neuroscience
Datasets as Topic
Sensory system
Stimulus (physiology)
Biology
Article
Visual motion
Mice
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Visual cortex
medicine.anatomical_structure
medicine
Animals
Functional organization
Neuroscience
030217 neurology & neurosurgery
Visual Cortex
Subjects
Details
- ISSN :
- 15461726 and 10976256
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Nature Neuroscience
- Accession number :
- edsair.doi.dedup.....9a971359dddf7e5e4fd8429b419d025b