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Screening for transfusion transmissible infections using rapid diagnostic tests in Africa: a potential hazard to blood safety?
- Source :
- Vox Sanguinis. 110:196-198
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- Rapid diagnostic tests (RDTs) are routinely used in African blood centres. We analysed data from two cross-sectional studies representing 95 blood centres in 29 African countries. Standardized panels of sera containing varying concentrations of anti-human immunodeficiency virus (HIV) antibodies (Ab), hepatitis B virus antigen (HBsAg) and antihepatitis C virus (HCV) Ab were screened using routine operational testing procedures at the centres. Sensitivity of detection using RDTs was high for HIV Ab-positive samples, but low for intermediately HBsAg (51·5%) and HCV Ab (40·6%)-positive samples. These findings suggest that current RDT use in Africa could pose a hazard to blood safety.
- Subjects :
- HBsAg
Blood transfusion
Blood Safety
medicine.medical_treatment
HIV Infections
030204 cardiovascular system & hematology
Article
Virus
03 medical and health sciences
0302 clinical medicine
parasitic diseases
Humans
Mass Screening
Medicine
Serologic Tests
Rapid diagnostic test
biology
Diagnostic Tests, Routine
business.industry
virus diseases
Diagnostic test
Hematology
General Medicine
Hepatitis C
Hepatitis B
medicine.disease
Virology
Africa
biology.protein
Antibody
business
030215 immunology
Subjects
Details
- ISSN :
- 00429007
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Vox Sanguinis
- Accession number :
- edsair.doi.dedup.....9a97b7f06af04f9454667cbb6f04d041