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Maternal CMV seroprevalence rate in early gestation and congenital cytomegalovirus infection in a Chinese population
- Source :
- Emerging Microbes & Infections, article-version (VoR) Version of Record
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis, 2021.
-
Abstract
- Background Congenital human cytomegalovirus (CMV) infection remains largely unrecognized and underemphasized in medical practice. This study aimed to describe the maternal CMV seroprevalence rate in early gestation and congenital CMV infection in a Chinese population. Methods This prospective cohort study was conducted in three hospitals in China from 2015 through 2018. Pregnant women were enrolled in early gestation and followed up in middle and late gestation with serological testing. CMV serostatus was determined by IgG testing in serum during early gestation. Their newborns were screened for cCMV infection by PCR testing in both saliva and urine at two time points. The cCMV prevalence, maternal seroprevalence and associated factors were analyzed. Results In China, the CMV seroprevalence was 98.11% (6602/6729, 95% CI: 97.76%–98.41%), and the cCMV prevalence was 1.32% (84/6350, 95% CI: 1.07%–1.64%). Over 98% of cCMV-positive newborns were from pregnant women who were seropositive in early gestation in China. The prevalence of cCMV infection in newborns from seropositive and seronegative pregnant women was similar (crude prevalence: 1.33% vs 0.82%, P = 1.00; estimated prevalence: 1.27% vs 1.05%, P = 0.32). Pregnant women who were under 25 years old or primiparous had a lower seroprevalence. Newborns from pregnant women under 25 years old or from twin pregnancies had a higher prevalence of cCMV infection. Conclusion in China, the cCMV prevalence was high, and the rates were similar in newborns from pregnant women who were seropositive and seronegative in early gestation. The vast majority of cCMV newborns were from seropositive mothers. Trial registration:ClinicalTrials.gov identifier: NCT02645396..
- Subjects :
- Human cytomegalovirus
Adult
Pediatrics
medicine.medical_specialty
China
Epidemiology
Immunology
prevalence
Congenital cytomegalovirus infection
Cytomegalovirus
Antibodies, Viral
Microbiology
Young Adult
Pregnancy
Seroepidemiologic Studies
Virology
Drug Discovery
medicine
Seroprevalence
Humans
Prospective Studies
Pregnancy Complications, Infectious
Chinese population
seroprevalence
business.industry
Early gestation
Infant, Newborn
virus diseases
Medical practice
General Medicine
medicine.disease
Infectious Disease Transmission, Vertical
congenital infection
Infectious Diseases
Immunoglobulin G
Cytomegalovirus Infections
DNA, Viral
Parasitology
Original Article
Female
business
pregnant women
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Emerging Microbes & Infections, article-version (VoR) Version of Record
- Accession number :
- edsair.doi.dedup.....9ac308f9664853ac99f7c1fac86fc12b
- Full Text :
- https://doi.org/10.6084/m9.figshare.16617053.v1