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Real-World Effectiveness of Once-Weekly Semaglutide From a US Commercially Insured and Medicare Advantage Population
- Source :
- Clinical therapeutics. 43(5)
- Publication Year :
- 2020
-
Abstract
- Purpose Patients managing type 2 diabetes mellitus (T2DM) often require combination therapy to meet their blood glucose control targets. With limited real-world evidence focused on the use of glucagon-like peptide 1 receptor agonist (GLP-1RA) therapies, the objective of this study was to describe the association between semaglutide once weekly (OW) initiation and changes in hemoglobin A1c (A1c) levels. Methods This retrospective, descriptive cohort study used the HealthCore Integrated Research Environment (HIRE) to examine commercially insured and Medicare Advantage patients who had T2DM while taking semaglutide OW from December 1, 2017, to April 30, 2019. The first semaglutide OW prescription fill was defined as the study index date. Changes in mean A1c levels and A1c target attainment were evaluated among an intention-to-treat (ITT) population (overall group). Furthermore, a persistent population (PP) analysis on the same outcomes was performed that was limited to ITT patients who were observed to continue to use semaglutide OW at the time of the postindex A1c measurement. In addition, these outcomes were explored in patients stratified based on prior use of GLP-1RA therapy (experienced vs naive) and baseline A1c values >9% (75 mmol/mol). Findings A total of 1888 patients were identified in the overall ITT group. The mean change in the overall ITT group between preindex and postindex A1c values was −0.9% percentage points (−9.8 mmol/mol) (mean preindex A1c, 8.2% [66.1 mmol/mol]) and −1.1 percentage points (−12.0 mmol/mol) (mean preindex A1c, 8.2% [66.1 mmol/mol]) in the PP subgroup (all P 9% (75 mmol/mol), percentage point changes in A1c were −2.2 (−24.0 mmol/mol) and −2.4 (−26.2 mmol/mol) (all P Implications Semaglutide OW is associated with clinically and statistically significant A1C reduction and increases in reaching A1 targets using real-world data, even in GLP-1RA–experienced patients, despite more frequent use of insulin or sodium glucose transport protein 2 inhibitors in this group. Target A1c attainment significantly increased overall and within all subgroups and strata, with approximately half of all patients attaining an A1c value
- Subjects :
- medicine.medical_specialty
endocrine system diseases
Combination therapy
Glucose control
Population
Glucagon-Like Peptides
Once weekly
02 engineering and technology
030204 cardiovascular system & hematology
Medicare Advantage
Glucagon-Like Peptide-1 Receptor
Cohort Studies
03 medical and health sciences
020210 optoelectronics & photonics
0302 clinical medicine
Internal medicine
0202 electrical engineering, electronic engineering, information engineering
medicine
Humans
Hypoglycemic Agents
Pharmacology (medical)
education
Aged
Retrospective Studies
Pharmacology
Glycated Hemoglobin
education.field_of_study
business.industry
Semaglutide
Percentage point
United States
Diabetes Mellitus, Type 2
Medicare Part C
business
Cohort study
Subjects
Details
- ISSN :
- 1879114X
- Volume :
- 43
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical therapeutics
- Accession number :
- edsair.doi.dedup.....9adb7e6a1785edf83c0ae2c7579c16a3