Back to Search
Start Over
The effect of 2000 ıu/day vitamin d supplementation on insulin resistance and cardiovascular risk parameters in vitamin d deficient obese adolescents
- Source :
- The Turkish Journal of Pediatrics. 61:723
- Publication Year :
- 2019
- Publisher :
- The Turkish Journal of Pediatrics, 2019.
-
Abstract
- Bilici ME, Savas Erdeve S, Cetinkaya S, Aycan Z. The effect of 2000 iu/day vitamin D supplementation on insulin resistance and cardiovascular risk parameters in vitamin D deficient obese adolescents. Turk J Pediatr 2019; 61: 723-732. The aim of this study was to determine the vitamin D deficiency prevalence in obese adolescents and to investigate the effect of vitamin D supplementation on insulin resistance and cardiovascular risk parameters in obese adolescents with vitamin D deficiency. Ninety-six obese adolescents aged 10-18 years were divided in 2 groups according to their vitamin D levels: Deficient group ( < 12ng/ ml) and sufficient group (≥12ng/ml). All patients in the vitamin D deficiency group were recommended 2000IU/day vitamin D supplementation. Fifty four (56.3%) patients had vitamin D deficiency. The only difference between the two groups was PTH level which was higher in the vitamin D deficiency group. Vitamin D reached sufficient levels in 22 (95.6%) out of the 23 patients with the 3 month supplementation of 2000 IU/day vitamin D. There was a significant decrease in weight Standard Deviation Score (SDS), Body Mass Index (BMI) SDS, hip circumference, total cholesterol, LDL, HbA1c, AST, PTH and interleukin-6 while no significant change was seen in measurements of glucose, insulin, HOMA-IR, C-peptide and the rate of metabolic syndrome. There were decreases in levels of total cholesterol and LDL with vitamin D treatment, while there was no significant change in insulin resistance. Vitamin D reduced interleukin-6 levels by its antiinflammatory effect.
- Subjects :
- Blood Glucose
Male
Vitamin
Pediatric Obesity
medicine.medical_specialty
Adolescent
medicine.medical_treatment
vitamin D deficiency
Body Mass Index
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Insulin resistance
Risk Factors
030225 pediatrics
Internal medicine
medicine
Vitamin D and neurology
Humans
Vitamin D
Child
business.industry
Insulin
Vitamins
Vitamin D Deficiency
medicine.disease
Obesity
Endocrinology
chemistry
Cardiovascular Diseases
Dietary Supplements
Pediatrics, Perinatology and Child Health
Female
Insulin Resistance
Metabolic syndrome
business
Body mass index
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00414301
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- The Turkish Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....9ae11571f7acc197896a3027d8431974