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Treatment of Refractory Takayasu Arteritis with Tocilizumab: 7 Italian Patients from a Single Referral Center

Authors :
Enrico Tombetti
Maria Grazia Sabbadini
Stefano Franchini
Elena Baldissera
Maurizio Papa
Source :
The Journal of Rheumatology. 40:2047-2051
Publication Year :
2013
Publisher :
The Journal of Rheumatology, 2013.

Abstract

Objective.The aim of our study was to evaluate the safety and the efficacy of tocilizumab (TCZ) for refractory Takayasu arteritis (TA).Methods.We retrospectively assessed the outcome of blocking interleukin (IL)-6 with TCZ in 7 consecutive patients with refractory TA using a combination of clinical and imaging assessment.Results.During a median followup visit at 14 months, 4 patients taking TCZ [including 2 nonresponders to tumor necrosis factor (TNF) inhibitors] achieved clinical response, suggesting a nonredundant role for IL-6 in TA. Inflammatory markers normalized in all patients treated with TCZ. However, vascular progression occurred in 4 patients, suggesting the involvement of other inflammatory pathways and confirming the limitations of erythrocyte sedimentation rate and C-reactive protein for disease activity assessment while taking TCZ. Three patients experienced adverse events and 2 suspended TCZ.Conclusion.TCZ may be effective in a subset of patients with refractory TA, even in cases of unresponsiveness to TNF inhibitors. Inflammatory markers are not valid markers of TA activity on TCZ. Further studies are needed to confirm these preliminary observations.

Details

ISSN :
14992752 and 0315162X
Volume :
40
Database :
OpenAIRE
Journal :
The Journal of Rheumatology
Accession number :
edsair.doi.dedup.....9aef7551800f35a705896d3a0b23bbea
Full Text :
https://doi.org/10.3899/jrheum.130536