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Magnetic-Composite-Modified Polycrystalline Silicon Nanowire Field-Effect Transistor for Vascular Endothelial Growth Factor Detection and Cancer Diagnosis
- Source :
- Analytical Chemistry. 86:9443-9450
- Publication Year :
- 2014
- Publisher :
- American Chemical Society (ACS), 2014.
-
Abstract
- This study proposes a vascular endothelial growth factor (VEGF) biosensor for diagnosing various stages of cervical carcinoma. In addition, VEGF concentrations at various stages of cancer therapy are determined and compared to data obtained by computed tomography (CT) and cancer antigen 125 (CA-125). The increase in VEGF concentrations during operations offers useful insight into dosage timing during cancer therapy. This biosensor uses Avastin as the biorecognition element for the potential cancer biomarker VEGF and is based on a n-type polycrystalline silicon nanowire field-effect transistor (poly-SiNW-FET). Magnetic nanoparticles with poly[aniline-co-N-(1-one-butyric acid) aniline]-Fe3O4 (SPAnH-Fe3O4) shell-core structures are used as carriers for Avastin loading and provide rapid purification due to their magnetic properties, which prevent the loss of bioactivity; furthermore, the high surface area of these structures increases the quantity of Avastin immobilized. Average concentrations in human blood for species that interfere with detection specificity are also evaluated. The detection range of the biosensor for serum samples covers the results expected from both healthy individuals and cancer patients.
- Subjects :
- Vascular Endothelial Growth Factor A
Silicon
Transistors, Electronic
Magnetic composite
Nanowire
Uterine Cervical Neoplasms
Nanotechnology
Biosensing Techniques
engineering.material
Antibodies, Monoclonal, Humanized
Analytical Chemistry
chemistry.chemical_compound
medicine
Humans
Neoplasm Staging
Nanowires
Carcinoma
Membrane Proteins
Cancer
medicine.disease
Ferrosoferric Oxide
Bevacizumab
Vascular endothelial growth factor
Polycrystalline silicon
chemistry
CA-125 Antigen
Magnets
engineering
Magnetic nanoparticles
Female
Field-effect transistor
Tomography, X-Ray Computed
Biosensor
Biomedical engineering
Subjects
Details
- ISSN :
- 15206882 and 00032700
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- Analytical Chemistry
- Accession number :
- edsair.doi.dedup.....9afa705225fbcf2809e2d052e71109a2