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Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review
- Source :
- BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-16 (2021), BMC Complementary Medicine and Therapies
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Lycium barbarum polysaccharide (LBP), the most abundant functional component of wolfberry, is considered a potent antioxidant and an anti-ageing substance. This review aims to outline the hallmarks of ageing in the pathogenesis of osteoarthritis (OA), followed by the current understanding of the senolytic effect of LBP and its potential use in the prevention and treatment of OA. This will be discussed through the lens of molecular biology and herbal medicine. Methods A literature search was performed from inception to March 2020 using following keywords: “Lycium barbarum polysaccharide”, “DNA damage”, antioxidant, anti-apoptosis, anti-inflammation, anti-ageing, osteoarthritis, chondrocytes, fibroblasts, osteoblasts, osteoclasts, and “bone mesenchymal stem cell”. The initial search yielded 2287 papers, from which 35 studies were selected for final analysis after screening for topic relevancy by the authors. Results In literature different in vitro and in vivo ageing models are used to demonstrate LBP’s ability to reduce oxidative stress, restore mitochondrial function, mitigate DNA damage, and prevent cellular senescence. All the evidence hints that LBP theoretically attenuates senescent cell accumulation and suppresses the senescence-associated secretory phenotype as observed by the reduction in pro-inflammatory cytokines, like interleukin-1beta, and matrix-degrading enzymes, such as MMP-1 and MMP-13. However, there remains a lack of evidence on the disease-modifying effect of LBP in OA, although its chondroprotective, osteoprotective and anti-inflammatory effects were reported. Conclusion Our findings strongly support further investigations into the senolytic effect of LBP in the context of age-related OA.
- Subjects :
- Aging
DNA damage
Anti-Inflammatory Agents
Context (language use)
Osteoarthritis
Pharmacology
medicine.disease_cause
Cellular senescence
Other systems of medicine
medicine
Humans
Senolytic
Lycium Barbarum polysaccharides
biology
business.industry
Mesenchymal stem cell
Reactive oxidative species
biology.organism_classification
medicine.disease
Complementary and alternative medicine
Ageing
Lycium
business
Mitochondrial dysfunction
Oxidative stress
RZ201-999
Drugs, Chinese Herbal
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 26627671
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Complementary Medicine and Therapies
- Accession number :
- edsair.doi.dedup.....9b1728cda98ff76697241b4b7ff07c33