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Quantitative 3D dynamic contrastâenhanced (DCE) MR imaging of carotid vessel wall by fast T1 mapping using Multitasking
- Source :
- Magnetic Resonance in Medicine. 81:2302-2314
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Author(s): Wang, Nan; Christodoulou, Anthony G; Xie, Yibin; Wang, Zhenjia; Deng, Zixin; Zhou, Bill; Lee, Sangeun; Fan, Zhaoyang; Chang, Hyukjae; Yu, Wei; Li, Debiao | Abstract: PurposeTo develop a dynamic contrast-enhanced (DCE) MRI method capable of high spatiotemporal resolution, 3D carotid coverage, and T1-based quantification of contrast agent concentration for the assessment of carotid atherosclerosis using a newly developed Multitasking technique.Methods5D imaging with 3 spatial dimensions, 1 T1 recovery dimension, and 1 DCE time dimension was performed using MR Multitasking based on low-rank tensor modeling, which allows direct T1 quantification with high spatiotemporal resolution (0.7 mm isotropic and 595 ms, respectively). Saturation recovery preparations followed by 3D segmented fast low angle shot readouts were implemented with Gaussian-density random 3D Cartesian sampling. A bulk motion removal scheme was developed to improve image quality. The proposed protocol was tested in phantom and human studies. In vivo scans were performed on 14 healthy subjects and 7 patients with carotid atherosclerosis. Kinetic parameters including area under the concentration versus time curve (AUC), vp , Ktrans , and ve were evaluated for each case.ResultsPhantom experiments showed that T1 measurements using the proposed protocol were in good agreement with reference value ( R 2 = 0.96 ). In vivo studies demonstrated that AUC, vp , and Ktrans in the patient group were significantly higher than in the control group (0.63 ± 0.13 versus 0.42 ± 0.12, P l 0.001; 0.14 ± 0.05 versus 0.11 ± 0.03, P = 0.034; and 0.13 ± 0.04 versus 0.08 ± 0.02, P l 0.001, respectively). Results from repeated subjects showed good interscan reproducibility (intraclass correlation coefficient: vp , 0.83; Ktrans , 0.87; ve , 0.92; AUC, 0.94).ConclusionMultitasking DCE is a promising approach for quantitatively assessing the vascularity properties of the carotid vessel wall.
- Subjects :
- Adult
Carotid Artery Diseases
Male
Carotid atherosclerosis
Time Factors
Intraclass correlation
Image quality
Normal Distribution
Contrast Media
Article
Imaging phantom
030218 nuclear medicine & medical imaging
Motion
03 medical and health sciences
Imaging, Three-Dimensional
0302 clinical medicine
Image Processing, Computer-Assisted
Humans
Human multitasking
Radiology, Nuclear Medicine and imaging
Aged
Mathematics
Aged, 80 and over
Reproducibility
Phantoms, Imaging
business.industry
Reproducibility of Results
Middle Aged
Magnetic Resonance Imaging
Mr imaging
Healthy Volunteers
Kinetics
Dynamic contrast
Carotid Arteries
Area Under Curve
Female
Nuclear medicine
business
Algorithms
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15222594 and 07403194
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Magnetic Resonance in Medicine
- Accession number :
- edsair.doi.dedup.....9b1a9ade80c18a1401648328adf1d6a9