Back to Search
Start Over
Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in saltāloaded metabolic syndrome rats
- Source :
- Annals of the New York Academy of Sciences.
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa /Leprfa (DS/obese) rats, an animal model of metabolic syndrome (MetS). DS/obese rats were subjected to surgical removal of iBAT or sham surgery at 8 weeks of age and were provided with drinking water containing or not containing 0.3% NaCl for 4 weeks beginning at 9 weeks of age. Removal of iBAT suppressed the salt-induced exacerbation of left ventricular inflammation, fibrosis, and diastolic dysfunction, but not that of hypertension development, in DS/obese rats. Salt loading attenuated adipocyte hypertrophy but enhanced inflammation in both visceral white adipose tissue (WAT) and iBAT. Although iBAT removal did not affect visceral WAT pathology in salt-loaded DS/obese rats, it attenuated the elevation of circulating interleukin-6 levels in these animals. Downregulation of uncoupling protein-1 expression in iBAT of DS/obese rats was not affected by salt loading. Our results suggest that the conversion of iBAT to WAT-like tissue contributes to a salt-induced elevation of circulating proinflammatory cytokine levels that leads to exacerbation of cardiac pathology in this model of MetS.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Adipose tissue
White adipose tissue
Intra-Abdominal Fat
030204 cardiovascular system & hematology
General Biochemistry, Genetics and Molecular Biology
Proinflammatory cytokine
Ventricular Dysfunction, Left
03 medical and health sciences
0302 clinical medicine
Adipose Tissue, Brown
History and Philosophy of Science
Fibrosis
Internal medicine
Brown adipose tissue
medicine
Animals
Obesity
Sodium Chloride, Dietary
Metabolic Syndrome
Rats, Inbred Dahl
business.industry
Myocardium
General Neuroscience
medicine.disease
Rats
Rats, Zucker
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Hypertension
Mutation
Cytokines
Receptors, Leptin
Inflammation Mediators
Metabolic syndrome
Adipocyte hypertrophy
business
Thermogenesis
Subjects
Details
- ISSN :
- 17496632 and 00778923
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi.dedup.....9b33c0e8eccccdb76e0ff1fad28ce2a4