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Abdominal Aortic Calcification is Associated with Diastolic Dysfunction, Mortality, and Nonfatal Cardiovascular Events in Maintenance Hemodialysis Patients

Authors :
Sungjin Chung
Hyeon Seok Hwang
Seok Joon Shin
Hyun Chul Whang
Hye Eun Yoon
Cheol Whee Park
Yu Ri Shin
Yong-Soo Kim
Hyun Wha Chung
Chul Woo Yang
Source :
Journal of Korean Medical Science
Publication Year :
2012
Publisher :
Korean Academy of Medical Sciences, 2012.

Abstract

This study evaluated the significance of aortic calcification index (ACI), an estimate of abdominal aortic calcification by plain abdominal computed tomography (CT), in terms of left ventricular (LV) diastolic dysfunction, mortality, and nonfatal cardiovascular (CV) events in chronic hemodialysis patients. Hemodialysis patients who took both an abdominal CT and echocardiography were divided into a low-ACI group (n = 64) and a high-ACI group (n = 64). The high-ACI group was significantly older, had a longer dialysis vintage and higher comorbidity indices, and more patients had a previous history of CV disease than the low-ACI group. The ACI was negatively correlated with LV end-diastolic volume or LV stroke volume, and was positively correlated with the ratio of peak early transmitral flow velocity to peak early diastolic mitral annular velocity (E/E' ratio), a marker of LV diastolic function. The E/E' ratio was independently associated with the ACI. The event-free survival rates for mortality and nonfatal CV events were significantly lower in the high-ACI group compared with those in the low-ACI group, and the ACI was an independent predictor for all-cause deaths and nonfatal CV events. In conclusion, ACI is significantly associated with diastolic dysfunction and predicts all-cause mortality and nonfatal CV events in hemodialysis patients.

Details

ISSN :
15986357 and 10118934
Volume :
27
Database :
OpenAIRE
Journal :
Journal of Korean Medical Science
Accession number :
edsair.doi.dedup.....9b44ec45637395e6c850a3221b7367e3
Full Text :
https://doi.org/10.3346/jkms.2012.27.8.870