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New approaches to antibiotic discovery
- Source :
- Biotechnology Letters. 39:805-817
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- New antibiotics are urgently required by human medicine as pathogens emerge with developed resistance to almost all antibiotic classes. Pioneering approaches, methodologies and technologies have facilitated a new era in antimicrobial discovery. Innovative culturing techniques such as iChip and co-culturing methods which use 'helper' strains to produce bioactive molecules have had notable success. Exploiting antibiotic resistance to identify antibacterial producers performed in tandem with diagnostic PCR based identification approaches has identified novel candidates. Employing powerful metagenomic mining and metabolomic tools has identified the antibiotic'ome, highlighting new antibiotics from underexplored environments and silent gene clusters enabling researchers to mine for scaffolds with both a novel mechanism of action and also few clinically established resistance determinants. Modern biotechnological approaches are delivering but will require support from government initiatives together with changes in regulation to pave the way for valuable, efficacious, highly targeted, pathogen specific antimicrobial therapies.
- Subjects :
- 0301 basic medicine
Silent gene
medicine.drug_class
Bioactive molecules
030106 microbiology
Antibiotics
Bioengineering
Computational biology
Biology
Applied Microbiology and Biotechnology
03 medical and health sciences
Antibiotic resistance
Drug Discovery
Human medicine
medicine
business.industry
General Medicine
Antimicrobial
Coculture Techniques
Streptomyces
Anti-Bacterial Agents
Biotechnology
Aspergillus
030104 developmental biology
Metagenomics
Identification (biology)
business
Subjects
Details
- ISSN :
- 15736776 and 01415492
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Biotechnology Letters
- Accession number :
- edsair.doi.dedup.....9b62b2e7dfd1228ade527cd31ffd3238