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The interaction of working memory performance and episodic memory formation in patients with Korsakoff's amnesia
- Source :
- Brain Research, 1433, pp. 98-103, Brain Research, 1433, 98-103
- Publication Year :
- 2012
-
Abstract
- Contains fulltext : 109864.pdf (Publisher’s version ) (Closed access) Both neuroimaging work and studies investigating amnesic patients have shown involvement of the medial temporal lobe during working memory tasks, especially when multiple items or features have to be associated. However, so far no study has examined the relationship between working memory and subsequent episodic memory in patients using similar tasks. In this study, we compared patients with amnesia due to Korsakoff's syndrome (n=19) with healthy controls (n=18) on an associative working memory task followed by an unexpected subsequent episodic memory task. The computerized working memory task required participants to maintain two pairs of faces and houses for either short (3s) or long (6s) delays. Approximately 5 minutes after completion of the working memory task, an unexpected subsequent recognition task with a two-alternative forced choice paradigm was administered. By directly comparing working memory and subsequent episodic memory, we were able to examine long-term encoding processes that may take place after longer delays. As expected, patients performed at chance level on the episodic memory task. Interestingly, patients also showed significantly impaired working memory performance (p
- Subjects :
- Adult
Male
Memory, Episodic
Short-term memory
Spatial memory
Reaction Time
Semantic memory
Humans
Visual short-term memory
Molecular Biology
Episodic memory
Autobiographical memory
Long-term memory
General Neuroscience
Memory rehearsal
Middle Aged
NCEBP 8 - Psychological determinants of chronic illness DCN PAC - Perception action and control
Korsakoff Syndrome
Memory, Short-Term
Case-Control Studies
Female
Neurology (clinical)
Amnesia
Psychology
Photic Stimulation
Psychomotor Performance
Developmental Biology
Cognitive psychology
Subjects
Details
- ISSN :
- 00068993
- Database :
- OpenAIRE
- Journal :
- Brain Research, 1433, pp. 98-103, Brain Research, 1433, 98-103
- Accession number :
- edsair.doi.dedup.....9b63c9b70f1a8a7ef16d66df19c6c52a