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The effect of potent antiretroviral therapy and JC virus load in cerebrospinal fluid on clinical outcome of patients with AIDS-associated progressive multifocal leukoencephalopathy
- Source :
- Università degli Studi di Siena-IRIS
- Publication Year :
- 2000
-
Abstract
- A multicenter analysis of 57 consecutive human immunodeficiency virus-positive patients with progressive multifocal leukoencephalopathy (PML) was performed, to identify correlates of longer survival. JC virus (JCV) DNA was quantified in the cerebrospinal fluid (CSF) by polymerase chain reaction. Two months after therapy, 4% of the patients without highly active antiretroviral therapy (HAART) and 26% with HAART showed neurologic improvement or stability (P=.03), and 8% and 57%, respectively, reached undetectable JCV DNA levels in the CSF (P=.04). One-year probability of survival was.04 without HAART and.46 with HAART. HAART and lack of neurologic progression 2 months after diagnosis were independently associated with longer survival. Among HAART-treated patients, a baseline JCV DNA
- Subjects :
- Adult
Male
medicine.medical_specialty
AIDS Dementia Complex
Time Factors
Anti-HIV Agents
viruses
JC virus
medicine.disease_cause
Gastroenterology
Polymerase Chain Reaction
Leukoencephalopathy
Pharmacotherapy
Internal medicine
Antiretroviral Therapy, Highly Active
medicine
Immunology and Allergy
Humans
Sida
Cerebrospinal Fluid
Retrospective Studies
Slow virus
biology
business.industry
Progressive multifocal leukoencephalopathy
Leukoencephalopathy, Progressive Multifocal
virus diseases
Viral Load
medicine.disease
biology.organism_classification
JC Virus
Infectious Diseases
Treatment Outcome
Immunology
DNA, Viral
RNA, Viral
Female
Viral disease
business
Viral load
Subjects
Details
- ISSN :
- 00221899
- Volume :
- 182
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of infectious diseases
- Accession number :
- edsair.doi.dedup.....9b99ad694acb5038bf9ddaf01d7be34e