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The effect of potent antiretroviral therapy and JC virus load in cerebrospinal fluid on clinical outcome of patients with AIDS-associated progressive multifocal leukoencephalopathy

Authors :
Maria Grazia Paglia
Adriana Ammassari
Andrea De Luca
Susanna Grisetti
Rita Murri
Maria Letizia Giancola
Antonella d'Arminio Monforte
Marco Gentile
Giuseppina Liuzzi
Andrea Antinori
Antonella Cingolani
Source :
Università degli Studi di Siena-IRIS
Publication Year :
2000

Abstract

A multicenter analysis of 57 consecutive human immunodeficiency virus-positive patients with progressive multifocal leukoencephalopathy (PML) was performed, to identify correlates of longer survival. JC virus (JCV) DNA was quantified in the cerebrospinal fluid (CSF) by polymerase chain reaction. Two months after therapy, 4% of the patients without highly active antiretroviral therapy (HAART) and 26% with HAART showed neurologic improvement or stability (P=.03), and 8% and 57%, respectively, reached undetectable JCV DNA levels in the CSF (P=.04). One-year probability of survival was.04 without HAART and.46 with HAART. HAART and lack of neurologic progression 2 months after diagnosis were independently associated with longer survival. Among HAART-treated patients, a baseline JCV DNA

Details

ISSN :
00221899
Volume :
182
Issue :
4
Database :
OpenAIRE
Journal :
The Journal of infectious diseases
Accession number :
edsair.doi.dedup.....9b99ad694acb5038bf9ddaf01d7be34e