Back to Search
Start Over
Left atrial strain is a predictor of left ventricular systolic and diastolic reverse remodelling in CRT candidates
- Source :
- European Heart Journal-Cardiovascular Imaging, European Heart Journal-Cardiovascular Imaging, 2022, 23 (10), pp.1373-1382. ⟨10.1093/ehjci/jeab163⟩, European Heart Journal-Cardiovascular Imaging, Oxford UP, 2021, ⟨10.1093/ehjci/jeab163⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- Aims The left atrium (LA) has a pivotal role in cardiac performance and LA deformation is a well-known prognostic predictor in several clinical conditions including heart failure with reduced ejection fraction. The aim of this study is to investigate the effect of cardiac resynchronization therapy (CRT) on both LA morphology and function and to assess the impact of LA reservoir strain (LARS) on left ventricular (LV) systolic and diastolic remodelling after CRT. Methods and results Two hundred and twenty-one CRT-candidates were prospectively included in the study in four tertiary centres and underwent echocardiography before CRT-implantation and at 6-month follow-up (FU). CRT-response was defined by a 15% reduction in LV end-systolic volume. LV systolic and diastolic remodelling were defined as the percent reduction in LV end-systolic and end-diastolic volume at FU. Indexed LA volume (LAVI) and LV-global longitudinal (GLS) strain were the main parameters correlated with LARS, with LV-GLS being the strongest determinant of LARS (r = −0.59, P < 0.0001). CRT induced a significant improvement in LAVI and LARS in responders (both P < 0.0001). LARS was an independent predictor of both LV systolic and diastolic remodelling at follow-up (r = −0.14, P = 0.049 and r = −0.17, P = 0.002, respectively). Conclusion CRT induces a significant improvement in LAVI and LARS in responders. In CRT candidates, the evaluation of LARS before CRT delivery is an independent predictor of LV systolic and diastolic remodelling at FU.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Heart Ventricles
Diastole
Cardiac resynchronization therapy
Left atrium
cardiac resynchronization therapy
heart failure
030204 cardiovascular system & hematology
Independent predictor
Left atrial strain
030218 nuclear medicine & medical imaging
03 medical and health sciences
Ventricular Dysfunction, Left
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Heart Atria
[SDV.IB] Life Sciences [q-bio]/Bioengineering
Ejection fraction
Heart Murmurs
left atrial strain
business.industry
General Medicine
medicine.disease
medicine.anatomical_structure
Treatment Outcome
Echocardiography
Heart failure
Cardiology
cardiovascular system
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 20472404 and 20472412
- Database :
- OpenAIRE
- Journal :
- European Heart Journal-Cardiovascular Imaging, European Heart Journal-Cardiovascular Imaging, 2022, 23 (10), pp.1373-1382. ⟨10.1093/ehjci/jeab163⟩, European Heart Journal-Cardiovascular Imaging, Oxford UP, 2021, ⟨10.1093/ehjci/jeab163⟩
- Accession number :
- edsair.doi.dedup.....9ba63acfc7e8ae7685b56cc8af28417c