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The influence of starvation and natural refeeding on the rate of triacylglycerol/fatty acid substrate cycling in brown adipose tissue and different white adipose sites of the rat in vivo. The role of insulin and the sympathetic nervous system
- Source :
- Bioscience Reports. 8:147-153
- Publication Year :
- 1988
- Publisher :
- Portland Press Ltd., 1988.
-
Abstract
- Triacylglycerol/fatty acid substrate cycling was measured in vivo in brown adipose tissue (BAT) and white adipose tissue (WAT) of fed, starved and refed rats. Starvation (24 h) significantly decreased the rate of cycling in BAT, and refeeding chow diet led to a rapid, 6-fold increase in cycling. Cycling rate in WAT was much lower than in BAT, and was not influenced by fasting or refeeding. Similar rates of cycling were found in epididymal, mesenteric, subcutaneous, and scapular WAT depots. Sympathetic denervation of interscapular BAT abolished the response of the tissue to refeeding, as did acute suppression of insulin secretion. Similarly, rats fasted for 3 days showed no acute increase in the activity of the cycle following refeeding.
- Subjects :
- Male
medicine.medical_specialty
Sympathetic nervous system
Sympathetic Nervous System
Mannoheptulose
medicine.medical_treatment
Substrate Cycling
Biophysics
Adipose tissue
White adipose tissue
Biology
Biochemistry
Adipose Tissue, Brown
Internal medicine
Brown adipose tissue
medicine
Animals
Insulin
Molecular Biology
Triglycerides
Starvation
chemistry.chemical_classification
Fatty Acids
nutritional and metabolic diseases
Fatty acid
Rats, Inbred Strains
Cell Biology
Denervation
Rats
medicine.anatomical_structure
Endocrinology
Adipose Tissue
chemistry
Food
medicine.symptom
Food Deprivation
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15734935 and 01448463
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....9bafdfaba61afe66ece1a1b3b900e81b