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MRI-Compatible Injection System for Magnetic Microparticle Embolization
- Source :
- IEEE transactions on bio-medical engineering. 66(8)
- Publication Year :
- 2018
-
Abstract
- Objective: Dipole field navigation and magnetic resonance navigation exploit B0 magnetic fields and imaging gradients for targeted intra-arterial therapies by using magnetic drug-eluting beads (MDEBs). The strong magnetic strength (1.5 or 3 T) of clinical magnetic resonance imaging (MRI) scanners is the main challenge preventing the formation and controlled injection of specific-sized particle aggregates. Here, an MRI-compatible injector is proposed to solve the above problem. Methods: The injector consists of two peristaltic pumps, an optical counter, and a magnetic trap. The magnetic property of microparticles, the magnetic compatibility of different parts within the injector, and the field distribution of the MRI system were studied to determine the optimal design and setup of the injector. The performance was investigated through 30.4-emu/g biocompatible magnetic microparticles (230 ± 35 μm in diameter) corresponding to the specifications needed for trans-arterial chemoembolization in human adults. Results: The system can form aggregates containing 20 to 60 microparticles with a precision of six particles. The corresponding aggregate lengths range from 1.6 to 3.2 mm. Based on the injections of 50 MRI-visible boluses into a phantom which mimics realistic physiological conditions, 82% of the aggregates successfully reached subbranches. Conclusion and Significance: This system has the capability to operate within the strong magnetic field of a clinical 3-T MRI, to form proper particle aggregates and to automatically inject these aggregates into the MRI bore. Moreover, the versatility of the proposed injector renders it suitable for selective injections of MDEBs during MR-guided embolization procedures.
- Subjects :
- Materials science
0206 medical engineering
Biomedical Engineering
Peristaltic pump
02 engineering and technology
Imaging phantom
law.invention
Injections
law
Magnetic trap
medicine
Humans
Microparticle
Particle Size
Magnetite Nanoparticles
medicine.diagnostic_test
Phantoms, Imaging
Liver Neoplasms
Magnetic resonance imaging
Injector
Equipment Design
equipment and supplies
020601 biomedical engineering
Embolization, Therapeutic
Magnetic Resonance Imaging
Magnetic field
human activities
Magnetic dipole
Biomedical engineering
Subjects
Details
- ISSN :
- 15582531
- Volume :
- 66
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- IEEE transactions on bio-medical engineering
- Accession number :
- edsair.doi.dedup.....9bb1a4a2e595c44bbe301544fc2c219f